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    SEC7-like guanine nucleotide exchange family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825257, updated on 18-Sep-2024

    Summary

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    Official Full Name
    SEC7-like guanine nucleotide exchange family protein
    Primary source
    TAIR:AT3G60860
    Locus tag
    AT3G60860
    See related
    Araport:AT3G60860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (22484397..22491935)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 65-4 Neighboring gene uncharacterized protein Neighboring gene AT-hook motif nuclear-localized protein 18 Neighboring gene dihydrodipicolinate synthase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana. Kitakura S, et al. Plant Cell Physiol, 2017 Oct 1. PMID 29016942
    2. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BEN3/BIG2 is an guanine nucleotide exchange factors for ADP ribosylation factor component, which confers brefeldin A sensitivity to the trans-Golgi Network/Early Endosome in Arabidopsis.[BEN3]
      Title: BEN3/BIG2 ARF GEF is Involved in Brefeldin A-Sensitive Trafficking at the trans-Golgi Network/Early Endosome in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115950.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SEC7-like guanine nucleotide exchange family protein
    NP_191645.1
    • SEC7-like guanine nucleotide exchange family protein; FUNCTIONS IN: binding, ARF guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity; INVOLVED IN: regulation of ARF protein signal transduction; LOCATED IN: intracellular; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: SEC7-like (InterPro:IPR000904), Armadillo-type fold (InterPro:IPR016024), Protein of unknown function DUF1981, SEC7 associated (InterPro:IPR015403); BEST Arabidopsis thaliana protein match is: SEC7-like guanine nucleotide exchange family protein (TAIR:AT1G01960.1); Has 2962 Blast hits to 2694 proteins in 246 species: Archae - 0; Bacteria - 33; Metazoa - 1475; Fungi - 672; Plants - 315; Viruses - 0; Other Eukaryotes - 467 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22484397..22491935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115950.4 → NP_191645.1  SEC7-like guanine nucleotide exchange family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LZX8
      UniProtKB/TrEMBL
      A0A654FJM2
      Conserved Domains (6) summary
      PLN03076
      Location:1 → 1793
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:617 → 799
      Sec7; Sec7 domain
      pfam09324
      Location:1166 → 1249
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:345 → 499
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:1346 → 1421
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:6 → 217
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZX8.1

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