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    MIRO2 MIRO-related GTP-ase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825490, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIRO2
    Official Full Name
    MIRO-related GTP-ase 2
    Primary source
    TAIR:AT3G63150
    Locus tag
    AT3G63150
    See related
    Araport:AT3G63150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCBG; CALCIUM BINDING GTP-ASE; MIRO-related GTP-ase 2
    Summary
    Encodes a calcium binding GTPases that is localized to the mitochondrion and is involved in salt stress response.
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    Genomic context

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    See MIRO2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (23328916..23333078, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RAN GTPase activating protein 1 Neighboring gene ncRNA Neighboring gene chloroplast stem-loop binding protein of 41 kDa Neighboring gene ncRNA Neighboring gene outer envelope membrane protein Neighboring gene Chalcone-flavanone isomerase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Miro2 tethers the ER to mitochondria to promote mitochondrial fusion in tobacco leaf epidermal cells. White RR, et al. Commun Biol, 2020 Apr 3. PMID 32246085, Free PMC Article
    2. Novel calcium-binding GTPase (AtCBG) involved in ABA-mediated salt stress signaling in Arabidopsis. Jayasekaran K, et al. Plant Cell Rep, 2006 Nov. PMID 16832621
    3. Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis. Sørmo CG, et al. PLoS One, 2011 Apr 11. PMID 21494602, Free PMC Article
    4. EMB2473/MIRO1, an Arabidopsis Miro GTPase, is required for embryogenesis and influences mitochondrial morphology in pollen. Yamaoka S, et al. Plant Cell, 2008 Mar. PMID 18344283, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Miro2 tethers the ER to mitochondria to promote mitochondrial fusion in tobacco leaf epidermal cells.
      Title: Miro2 tethers the ER to mitochondria to promote mitochondrial fusion in tobacco leaf epidermal cells.
    2. MIRO1 and MIRO2 are unequally redundant and that a proportion of the miro1(+/-)/miro2(-/-) plants haploid gametes displays the complete null phenotype of MIRO GTPase function at key developmental stages.
      Title: Arabidopsis thaliana MIRO1 and MIRO2 GTPases are unequally redundant in pollen tube growth and fusion of polar nuclei during female gametogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_116180.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MIRO-related GTP-ase 2
    NP_567139.1
    • MIRO-related GTP-ase 2 (MIRO2); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF hand associated, type-1 (InterPro:IPR013566), EF hand associated, type-2 (InterPro:IPR013567), Mitochondrial Rho-like (InterPro:IPR013684), Small GTPase, Rho type (InterPro:IPR003578), Ras GTPase (InterPro:IPR001806), Ras small GTPase, Rab type (InterPro:IPR003579), Mitochondrial Rho GTPase (InterPro:IPR021181), EF-HAND 2 (InterPro:IPR018249), MIRO (InterPro:IPR020860); BEST Arabidopsis thaliana protein match is: MIRO-related GTP-ase 1 (TAIR:AT5G27540.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23328916..23333078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116180.4 → NP_567139.1  MIRO-related GTP-ase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J0W4, Q93Z33, Q9LYA8
      UniProtKB/TrEMBL
      A0A178VC39, A0A5S9XNC6
      Conserved Domains (4) summary
      cd01892
      Location:422 → 604
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:13 → 180
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:352 → 417
      EF_assoc_1; EF hand associated
      pfam08356
      Location:230 → 313
      EF_assoc_2; EF hand associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4J0W4.1

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