U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GDH2 glutamate dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830635, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GDH2
    Official Full Name
    glutamate dehydrogenase 2
    Primary source
    TAIR:AT5G07440
    Locus tag
    AT5G07440
    See related
    Araport:AT5G07440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glutamate dehydrogenase 2; GLUTAMATE DEHYDROGENASE 2; T2I1.150; T2I1_150
    Summary
    Encodes the beta-subunit of the glutamate dehydrogenase. The enzyme is almost exclusively found in the mitochondria of stem and leaf companion cells.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GDH2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (2355759..2358241)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene miscRNA Neighboring gene cyclin p4;3 Neighboring gene peptidemethionine sulfoxide reductase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nitrogen recycling and remobilization are differentially controlled by leaf senescence and development stage in Arabidopsis under low nitrogen nutrition. Diaz C, et al. Plant Physiol, 2008 Jul. PMID 18467460, Free PMC Article
    2. Induction of Arabidopsis gdh2 gene expression during changes in redox state of the mitochondrial respiratory chain. Tarasenko VI, et al. Biochemistry (Mosc), 2009 Jan. PMID 19232048
    3. Characterization and expression of NAD(H)-dependent glutamate dehydrogenase genes in Arabidopsis. Turano FJ, et al. Plant Physiol, 1997 Apr. PMID 9112779, Free PMC Article
    4. Control of the synthesis and subcellular targeting of the two GDH genes products in leaves and stems of Nicotiana plumbaginifolia and Arabidopsis thaliana. Fontaine JX, et al. Plant Cell Physiol, 2006 Mar. PMID 16418233
    5. NAD(H)-dependent glutamate dehydrogenase is essential for the survival of Arabidopsis thaliana during dark-induced carbon starvation. Miyashita Y, et al. J Exp Bot, 2008. PMID 18296429

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
      Title: High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
    2. these data illustrate the essential role of EIN3-regulated GDH activity in metabolic adjustment during anoxia-reoxygenation.
      Title: Ethylene-Regulated Glutamate Dehydrogenase Fine-Tunes Metabolism during Anoxia-Reoxygenation.
    3. Protein phosphorylation by serine/threonine protein kinases is the essential step required for signal transduction into nucleus resulting in the induction of glutamate dehydrogenase 2 expression.
      Title: Induction of Arabidopsis gdh2 gene expression during changes in redox state of the mitochondrial respiratory chain.
    4. role in amino acid breakdown under C-deficient conditions
      Title: NAD(H)-dependent glutamate dehydrogenase is essential for the survival of Arabidopsis thaliana during dark-induced carbon starvation.
    5. In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate dehydrogenase are targeted to the mitochondria of the companion cells.
      Title: Control of the synthesis and subcellular targeting of the two GDH genes products in leaves and stems of Nicotiana plumbaginifolia and Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001125711.2
    NM_001125712.2
    NM_120826.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables cobalt ion binding HDA PubMed 
    enables copper ion binding HDA PubMed 
    enables glutamate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate dehydrogenase 2
    NP_001119183.1
    • glutamate dehydrogenase 2 (GDH2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), Glutamate dehydrogenase (InterPro:IPR014362), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 1 (TAIR:AT5G18170.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001119184.1
    • glutamate dehydrogenase 2 (GDH2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 3 (TAIR:AT3G03910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_196361.1
    • glutamate dehydrogenase 2 (GDH2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), Glutamate dehydrogenase (InterPro:IPR014362), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 1 (TAIR:AT5G18170.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2355759..2358241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120826.3 → NP_196361.1  glutamate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38946
      UniProtKB/TrEMBL
      A0A178UEW8, A0A5S9Y275, A0A7G2F914
      Conserved Domains (1) summary
      PLN02477
      Location:1 → 410
      PLN02477; glutamate dehydrogenase

    2. NM_001125711.2 → NP_001119183.1  glutamate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119183.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38946
      UniProtKB/TrEMBL
      A0A178UEW8, A0A5S9Y275, A0A7G2F914
      Conserved Domains (1) summary
      PLN02477
      Location:1 → 410
      PLN02477; glutamate dehydrogenase

    3. NM_001125712.2 → NP_001119184.1  glutamate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z209, F4K6P9
      Conserved Domains (3) summary
      PLN02477
      Location:1 → 296
      PLN02477; glutamate dehydrogenase
      pfam02812
      Location:31 → 159
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain
      cl21454
      Location:176 → 296
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38946.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools