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    CaS calcium sensing receptor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832370, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CaS
    Official Full Name
    calcium sensing receptor
    Primary source
    TAIR:AT5G23060
    Locus tag
    AT5G23060
    See related
    Araport:AT5G23060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    calcium sensing receptor; MYJ24.5; MYJ24_5
    Summary
    Encodes a chloroplast-localized protein that modulates cytoplasmic Ca2+ concentration and is crucial for proper stomatal regulation in response to elevations of external Ca2+. Phosphorylation of this protein is dependent on calcium.
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    Genomic context

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    See CaS in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (7736518..7738535, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene cell growth defect factor-like protein (DUF3353) Neighboring gene acyl-activating enzyme 17 Neighboring gene miscRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the calcium-sensing receptor in both stomatal movement and photosynthetic electron transport is crucial for water use efficiency and drought tolerance in Arabidopsis. Wang WH, et al. J Exp Bot, 2014 Jan. PMID 24187420, Free PMC Article
    2. Calcium and calcium receptor CAS promote Arabidopsis thaliana de-etiolation. Huang SS, et al. Physiol Plant, 2012 Jan. PMID 21919914
    3. A plastid protein crucial for Ca2+-regulated stomatal responses. Weinl S, et al. New Phytol, 2008. PMID 18507772
    4. Light regulation of CaS, a novel phosphoprotein in the thylakoid membrane of Arabidopsis thaliana. Vainonen JP, et al. FEBS J, 2008 Apr. PMID 18331354
    5. Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis. Tang RH, et al. Science, 2007 Mar 9. PMID 17347443

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calcium-sensing receptor (CAS) regulates transpiration and optimizes photosynthesis by playing important roles in stomatal movement and formation of photosynthetic electron transport, thereby regulating WUE and drought tolerance.
      Title: Regulation of the calcium-sensing receptor in both stomatal movement and photosynthetic electron transport is crucial for water use efficiency and drought tolerance in Arabidopsis.
    2. A mutation in CAU1 significantly increased the expression level of the calcium signaling gene CAS, and functional disruption of CAS abolished the enhanced drought tolerance and stomatal [Ca(2+)]o signaling in cau1.
      Title: Arabidopsis histone methylase CAU1/PRMT5/SKB1 acts as an epigenetic suppressor of the calcium signaling gene CAS to mediate stomatal closure in response to extracellular calcium.
    3. CAS is a chloroplast-localized protein that is crucial for proper stomatal regulation in response to elevations of external Ca(2+).
      Title: A plastid protein crucial for Ca2+-regulated stomatal responses.
    4. Arabidopsis lines revealed a significant role for calcium-sensing receptor (CaS) in plant growth and development. [calcium-sensing receptor] [CaS]
      Title: Light regulation of CaS, a novel phosphoprotein in the thylakoid membrane of Arabidopsis thaliana.
    5. results show [Ca2+]i oscillations are synchronized to extracellular Ca2+ concentration oscillations largely through Ca2+-sensing receptor CAS; CAS regulates inositol 1,4,5-trisphosphate concentration which directs release of Ca2+ from internal stores
      Title: Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001343788.1
    NM_122212.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in de-etiolation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in de-etiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plastid HDA PubMed 
    located_in thylakoid HDA PubMed 
    located_in thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium sensing receptor
    NP_197697.1
    • calcium sensing receptor (CaS); INVOLVED IN: regulation of stomatal closure, cellular response to calcium ion; LOCATED IN: thylakoid, mitochondrion, chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763); BEST Arabidopsis thaliana protein match is: Rhodanese/Cell cycle control phosphatase superfamily protein (TAIR:AT3G59780.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7736518..7738535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122212.5 → NP_197697.1  calcium sensing receptor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FN48
      UniProtKB/TrEMBL
      A0A178UBZ3, A0A5S9Y6T9, A0A654G3C2
      Conserved Domains (1) summary
      cd00158
      Location:225 → 339
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    2. NM_001343788.1 → NP_001331124.1  calcium sensing receptor [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UBZ3, A0A1P8BCX7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FN48.1

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