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    Succinyl-CoA ligase, alpha subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832389, updated on 10-Oct-2024

    Summary

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    Official Full Name
    Succinyl-CoA ligase, alpha subunit
    Primary source
    TAIR:AT5G23250
    Locus tag
    AT5G23250
    See related
    Araport:AT5G23250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MKD15.11; MKD15_11
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (7830318..7832843)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNAJ heat shock N-terminal domain-containing protein Neighboring gene nicotinamidase 2 Neighboring gene miscRNA Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene sugar transporter 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    2. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
    3. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125791.2
    NM_001343795.1
    NM_122231.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables succinate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Succinyl-CoA ligase, alpha subunit
    NP_001119263.1
    • Succinyl-CoA ligase, alpha subunit; FUNCTIONS IN: succinate-CoA ligase (GDP-forming) activity, copper ion binding; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Succinyl-CoA ligase, alpha subunit (InterPro:IPR005810), ATP-citrate lyase/succinyl-CoA ligase (InterPro:IPR005811), NAD(P)-binding domain (InterPro:IPR016040), ATP-citrate lyase/succinyl-CoA ligase, active site (InterPro:IPR017440), CoA-binding (InterPro:IPR003781), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: Succinyl-CoA ligase, alpha subunit (TAIR:AT5G08300.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_197716.1
    • Succinyl-CoA ligase, alpha subunit; FUNCTIONS IN: succinate-CoA ligase (GDP-forming) activity, copper ion binding; INVOLVED IN: metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Succinyl-CoA ligase, alpha subunit (InterPro:IPR005810), ATP-citrate lyase/succinyl-CoA ligase (InterPro:IPR005811), NAD(P)-binding domain (InterPro:IPR016040), CoA-binding (InterPro:IPR003781), ATP-citrate lyase/succinyl-CoA ligase, active site (InterPro:IPR017440), Succinyl-CoA synthetase-like (InterPro:IPR016102); BEST Arabidopsis thaliana protein match is: Succinyl-CoA ligase, alpha subunit (TAIR:AT5G08300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7830318..7832843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001125791.2 → NP_001119263.1  Succinyl-CoA ligase, alpha subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UAS6, B3H632
      Conserved Domains (3) summary
      PTZ00187
      Location:30 → 295
      PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
      pfam02629
      Location:50 → 143
      CoA_binding; CoA binding domain
      cl22543
      Location:196 → 295
      Ligase_CoA; CoA-ligase

    2. NM_122231.4 → NP_197716.1  Succinyl-CoA ligase, alpha subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAD2, Q9FMX5
      UniProtKB/TrEMBL
      A0A178UAS6, A0A5S9Y6V8, A0A654G3K0
      Conserved Domains (1) summary
      PLN00125
      Location:41 → 340
      PLN00125; Succinyl-CoA ligase [GDP-forming] subunit alpha

    3. NM_001343795.1 → NP_001331781.1  Succinyl-CoA ligase, alpha subunit [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEZ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LAD2.2

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