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    CBL2 calcineurin B-like protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835697, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBL2
    Official Full Name
    calcineurin B-like protein 2
    Primary source
    TAIR:AT5G55990
    Locus tag
    AT5G55990
    See related
    Araport:AT5G55990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCBL2; calcineurin B-like protein 2; MDA7.3; MDA7_3; SCaBP1; SOS3-LIKE CALCIUM BINDING PROTEIN 1
    Summary
    Encodes a member of the Arabidopsis CBL (Calcineurin B-like Calcium Sensor) protein family.
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    Genomic context

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    See CBL2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (22671113..22674100)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene serine-rich protein-like protein Neighboring gene HEAT SHOCK PROTEIN 81.4 Neighboring gene heat shock protein 81-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14. Akaboshi M, et al. J Mol Biol, 2008 Mar 14. PMID 18237745
    2. The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana. Eckert C, et al. Plant J, 2014 Apr. PMID 24479654
    3. Dual fatty acyl modification determines the localization and plasma membrane targeting of CBL/CIPK Ca2+ signaling complexes in Arabidopsis. Batistic O, et al. Plant Cell, 2008 May. PMID 18502848, Free PMC Article
    4. Calcineurin B-Like Protein-Interacting Protein Kinase CIPK21 Regulates Osmotic and Salt Stress Responses in Arabidopsis. Pandey GK, et al. Plant Physiol, 2015 Sep. PMID 26198257, Free PMC Article
    5. Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth. Steinhorst L, et al. Curr Biol, 2015 Jun 1. PMID 25936548

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crucial regulator of vacuolar dynamics and polarized pollen tube growth
      Title: Vacuolar CBL-CIPK12 Ca(2+)-sensor-kinase complexes are required for polarized pollen tube growth.
    2. the calcium-independent activation of PKS24 by SCaBP1 is dependent on interaction of PKS24 with the C-terminal tail of SCaBP1. [SCaBP1]
      Title: A calcium-independent activation of the Arabidopsis SOS2-like protein kinase24 by its interacting SOS3-like calcium binding protein1.
    3. While single cbl2 or cbl3 mutants did not display discernable phenotypes, cbl2/cbl3 mutants exhibited defects in vegetative growth and were severely impaired in seed development and morphology.
      Title: The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana.
    4. CBL2-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane compartments, the apical plasma membrane (PM), and cytoskeleton-like structures in pollen tubes. v
      Title: A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes.
    5. Structural comparison of the two structures shows that the recognition of CBL by CIPK is performed in a similar manner, but inherent interactions confer binding affinity and specificity.
      Title: The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124981.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosolic ribosome HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    calcineurin B-like protein 2
    NP_200410.1
    • calcineurin B-like protein 2 (CBL2); FUNCTIONS IN: calcium ion binding; INVOLVED IN: calcium-mediated signaling; LOCATED IN: cytosolic ribosome, plant-type vacuole membrane, vacuole, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like 3 (TAIR:AT4G26570.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22671113..22674100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001345176.1 → NP_001332655.1  calcineurin B-like protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81446, Q8LAS7
      UniProtKB/TrEMBL
      A0A178UCE4, A0A654GBV2
      Conserved Domains (1) summary
      COG5126
      Location:36 → 198
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_124981.4 → NP_200410.1  calcineurin B-like protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200410.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81446, Q8LAS7
      UniProtKB/TrEMBL
      A0A178UCE4, A0A654GBV2
      Conserved Domains (1) summary
      COG5126
      Location:36 → 198
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LAS7.2

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