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    ERL1 ERECTA-like 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836344, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERL1
    Official Full Name
    ERECTA-like 1
    Primary source
    TAIR:AT5G62230
    Locus tag
    AT5G62230
    See related
    Araport:AT5G62230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ERECTA-like 1; MMI9.14; MMI9_14
    Summary
    Encodes a receptor-like kinase that, together with ER and ERL2 governs the initial decision of protodermal cells to either divide proliferatively to produce pavement cells or divide asymmetrically to generate stomatal complexes. It is important for maintaining stomatal stem cell activity and preventing terminal differentiation of the meristemoid into the guard mother cell. Along with erl2 functionally compensates for loss of erecta during integument development. Its transcript levels change after inducing MUTE expression in a mute background.
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    Genomic context

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    See ERL1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    27
    Sequence:
    Chromosome: 5; NC_003076.8 (24996129..25002439)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glycosyltransferase 18 Neighboring gene ncRNA Neighboring gene Cell cycle regulated microtubule associated protein Neighboring gene microtubule-associated protein 65-9 Neighboring gene AT hook motif DNA-binding family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERECTA-family receptor kinase genes redundantly prevent premature progression of secondary growth in the Arabidopsis hypocotyl. Ikematsu S, et al. New Phytol, 2017 Mar. PMID 27891614
    2. ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity. Nanda AK, et al. J Exp Bot, 2019 Nov 18. PMID 31504732, Free PMC Article
    3. A receptor-like protein acts as a specificity switch for the regulation of stomatal development. Lin G, et al. Genes Dev, 2017 May 1. PMID 28536146, Free PMC Article
    4. Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling. Qi X, et al. Elife, 2017 Mar 7. PMID 28266915, Free PMC Article
    5. Regulation of floral patterning and organ identity by Arabidopsis ERECTA-family receptor kinase genes. Bemis SM, et al. J Exp Bot, 2013 Dec. PMID 24006425

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity.
      Title: ERECTA receptor-kinases play a key role in the appropriate timing of seed germination under changing salinity.
    2. ER and ERL1 redundantly prevent premature progression of sequential events in secondary growth.
      Title: ERECTA-family receptor kinase genes redundantly prevent premature progression of secondary growth in the Arabidopsis hypocotyl.
    3. Here, the authors report that EPF1 and its primary receptor ERECTA-LIKE1 (ERL1) target MUTE, a transcription factor specifying the proliferation-to-differentiation switch within the stomatal cell lineages. In turn, MUTE directly induces ERL1.
      Title: Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling.
    4. ER-family signalling is crucial for ensuring proper expression domains of floral meristem and floral organ identity determinants, and further implies the existence of a non-canonical downstream pathway.
      Title: Regulation of floral patterning and organ identity by Arabidopsis ERECTA-family receptor kinase genes.
    5. ER, ERL1 and ERL2 proteins are essential for PIN1 expression in the forming midvein of future leaf primordia and in the vasculature of emerging leaves.
      Title: ERECTA family genes regulate auxin transport in the shoot apical meristem and forming leaf primordia.
    6. The ER family regulates stem cell homeostasis via buffering its cytokinin responsiveness in the Shoot apical meristem (SAM).
      Title: ERECTA-family receptor kinases regulate stem cell homeostasis via buffering its cytokinin responsiveness in the shoot apical meristem.
    7. Both ER/ERL1/ERL2 and MPK3/MPK6 play important roles in normal anther lobe formation and anther cell differentiation.
      Title: Regulation of Arabidopsis early anther development by the mitogen-activated protein kinases, MPK3 and MPK6, and the ERECTA and related receptor-like kinases.
    8. ERL2 is haploinsufficient for maintaining female fertility in the absence of ER and ERL1.
      Title: Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development.
    9. Three ERECTA-family leucine-rich repeat-receptor-like kinases (ER, ERL1,ERL2) together control stomatal patterning, with specific family members regulating specification of stomatal stem cell fate & differentiation of guard cells. [ERL1]
      Title: Stomatal patterning and differentiation by synergistic interactions of receptor kinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203666.1
    NM_125617.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ERECTA-like 1
    NP_001190595.1
    • ERECTA-like 1 (ERL1); FUNCTIONS IN: kinase activity; INVOLVED IN: stomatal complex morphogenesis, embryo sac development, ovule development; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat, typical subtype (InterPro:IPR003591), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: ERECTA-like 2 (TAIR:AT5G07180.1).
    NP_201029.1
    • ERECTA-like 1 (ERL1); FUNCTIONS IN: kinase activity; INVOLVED IN: stomatal complex morphogenesis, embryo sac development, ovule development; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ERECTA-like 2 (TAIR:AT5G07180.1); Has 222426 Blast hits to 137934 proteins in 3754 species: Archae - 152; Bacteria - 22676; Metazoa - 73214; Fungi - 10790; Plants - 88135; Viruses - 480; Other Eukaryotes - 26979 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24996129..25002439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203666.1 → NP_001190595.1  ERECTA-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UB72, F4K6F3
      Conserved Domains (5) summary
      PLN00113
      Location:12 → 868
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd00116
      Location:120 → 215
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:97 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:27 → 67
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:606 → 866
      PKc_like; Protein Kinases, catalytic domain

    2. NM_125617.3 → NP_201029.1  ERECTA-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201029.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGW6, Q6XAT3, Q8GXT4, Q9LVB3
      UniProtKB/TrEMBL
      A0A178UB72, A0A5S9YGT9, A0A654GDB1
      Conserved Domains (2) summary
      PLN00113
      Location:12 → 916
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:266 → 287
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0LGW6.1

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