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    SNC1 TIR-NBS-LRR class disease resistance protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827397, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SNC1
    Official Full Name
    TIR-NBS-LRR class disease resistance protein
    Primary source
    TAIR:AT4G16890
    Locus tag
    AT4G16890
    See related
    Araport:AT4G16890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BAL; BALL; CONSTITUTIVE 1; DL4475C; FCAALL.51; SUPPRESSOR OF NPR1-1
    Summary
    Encodes a Toll Interleukin1 receptor-nucleotide binding-Leu- rich repeat-type resistance gene (TIR-NB-LRR-type) involved in the salicylic acid-dependent defense response pathway. Mutant plants constitutively express pathogenesis-related (PR) genes and are pathogen resistant. Resistance signaling in snc1 requires EDS1, MOS3 and PAD4.
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    Genomic context

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    See SNC1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (9500271..9505972, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temperature modulates plant defense responses through NB-LRR proteins. Zhu Y, et al. PLoS Pathog, 2010 Apr 1. PMID 20368979, Free PMC Article
    2. P-loop-dependent NLR SNC1 can oligomerize and activate immunity in the nucleus. Xu F, et al. Mol Plant, 2014 Dec. PMID 25237053
    3. Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. Xu F, et al. Plant Cell, 2015 May. PMID 25966763, Free PMC Article
    4. Constitutive Expresser of Pathogenesis Related Genes 1 Is Required for Pavement Cell Morphogenesis in Arabidopsis. Han B, et al. PLoS One, 2015. PMID 26193674, Free PMC Article
    5. Crystal structure of Arabidopsis thaliana SNC1 TIR domain. Hyun KG, et al. Biochem Biophys Res Commun, 2016 Dec 2. PMID 27818198

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector.
      Title: The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector.
    2. Puncta-localized TRAF domain protein TC1b contributes to the autoimmunity of snc1.
      Title: Puncta-localized TRAF domain protein TC1b contributes to the autoimmunity of snc1.
    3. The intracellular immune receptor like gene SNC1 is an enhancer of effector-triggered immunity in Arabidopsis.
      Title: The intracellular immune receptor like gene SNC1 is an enhancer of effector-triggered immunity in Arabidopsis.
    4. In situ deletions reveal regulatory components for expression of an intracellular immune receptor gene and its co-expressed genes in Arabidopsis.
      Title: In situ deletions reveal regulatory components for expression of an intracellular immune receptor gene and its co-expressed genes in Arabidopsis.
    5. The novel pathogen-responsive glycosyltransferase UGT73C7 mediates the redirection of phenylpropanoid metabolism and promotes SNC1-dependent Arabidopsis immunity.
      Title: The novel pathogen-responsive glycosyltransferase UGT73C7 mediates the redirection of phenylpropanoid metabolism and promotes SNC1-dependent Arabidopsis immunity.
    6. BONZAI Proteins Control Global Osmotic Stress Responses in Plants.
      Title: BONZAI Proteins Control Global Osmotic Stress Responses in Plants.
    7. Functional requirement of the Arabidopsis importin-alpha nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
      Title: Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
    8. PTRE1 acts as a negative regulator of plant immunity partly by facilitating the degradation of immune receptors such as SNC1.
      Title: The proteasome regulator PTRE1 contributes to the turnover of SNC1 immune receptor.
    9. Study propose that allelic diversity at SNC1 contributes to the maintenance of the hyperactive ACD6 variant in natural A. thaliana populations.
      Title: Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene.
    10. The disease resistance protein SNC1 represses the biogenesis of microRNAs and phased siRNAs.
      Title: The disease resistance protein SNC1 represses the biogenesis of microRNAs and phased siRNAs.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341145.1
    NM_001341147.1
    NM_001341148.1
    NM_001341149.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within innate immune response-activating signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TIR-NBS-LRR class disease resistance protein
    NP_001319970.1
    • SUPPRESSOR OF NPR1-1, CONSTITUTIVE 1 (SNC1); FUNCTIONS IN: nucleotide binding; INVOLVED IN: response to auxin stimulus, defense response to bacterium, incompatible interaction, defense response, systemic acquired resistance, salicylic acid mediated signaling pathway; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G16920.1); Has 42615 Blast hits to 22768 proteins in 878 species: Archae - 40; Bacteria - 3631; Metazoa - 4485; Fungi - 289; Plants - 31985; Viruses - 14; Other Eukaryotes - 2171 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9500271..9505972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341146.1 → NP_001329720.1  TIR-NBS-LRR class disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8K1, A0A346XQL9

    2. NM_001341145.1 → NP_001319970.1  TIR-NBS-LRR class disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23530
      UniProtKB/TrEMBL
      A0A346XQL9
      Conserved Domains (3) summary
      COG4886
      Location:619 → 869
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:854 → 874
      LRR_RI; leucine-rich repeat [structural motif]
      cl27891
      Location:13 → 1346
      LRR_3; Leucine Rich Repeat

    3. NM_001341148.1 → NP_001329722.1  TIR-NBS-LRR class disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8K8

    4. NM_001341147.1 → NP_001329719.1  TIR-NBS-LRR class disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8L1, A0A346XQL9

    5. NM_001341149.1 → NP_001329721.1  TIR-NBS-LRR class disease resistance protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8K4, A0A346XQL9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23530.5

    Gene LinkOut

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