Formyl transferase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Formyl transferase
Primary source: TAIR:AT4G17360
Locus tag: AT4G17360
See related: Araport:AT4G17360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DL4715C; FCAALL.417
Summary: encodes one of the two putative formyltetrahydrofolate deformylase. Located in the mitochondrion. Involved in photorespiratory tetrahydrofolate cycle.
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (9703547..9705664, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings are consistent with the involvement of At4g17360 and At5g47435 proteins in photorespiration, which is to prevent excessive accumulation of 5-formyl THF, a potent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex.
Title: Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001341216.1

Supported by ESTs:

NM_001341217.1

Supported by ESTs:

NM_117840.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables formyltetrahydrofolate deformylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photorespiration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tetrahydrofolate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Formyl transferase

NP_193467.2

Formyl transferase; FUNCTIONS IN: methyltransferase activity, hydroxymethyl-, formyl- and related transferase activity, formyltetrahydrofolate deformylase activity; INVOLVED IN: tetrahydrofolate metabolic process, purine ribonucleotide biosynthetic process, biosynthetic process, photorespiration; LOCATED IN: mitochondrion; EXPRESSED IN: sperm cell; CONTAINS InterPro DOMAIN/s: Phosphoribosylglycinamide formyltransferase, active site (InterPro:IPR001555), Formyltetrahydrofolate deformylase (InterPro:IPR004810), Formyl transferase, N-terminal (InterPro:IPR002376); BEST Arabidopsis thaliana protein match is: formyltetrahydrofolate deformylase, putative (TAIR:AT5G47435.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

9703547..9705664 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117840.5 → NP_193467.2 Formyl transferase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193467.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JP46, O23579

UniProtKB/TrEMBL

A0A178V3Y8, A0A178V5S5, A0A5S9XU00

Conserved Domains (1) summary

PLN02828
Location:61 → 328

PLN02828; formyltetrahydrofolate deformylase
NM_001341216.1 → NP_001328419.1 Formyl transferase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B4L8
NM_001341217.1 → NP_001328420.1 Formyl transferase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B4M0