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    VRN2 VEFS-Box of polycomb protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827392, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VRN2
    Official Full Name
    VEFS-Box of polycomb protein
    Primary source
    TAIR:AT4G16845
    Locus tag
    AT4G16845
    See related
    Araport:AT4G16845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    REDUCED VERNALIZATION RESPONSE 2
    Summary
    The VERNALIZATION2 (VRN2) gene mediates vernalization and encodes a nuclear-localized zinc finger protein with similarity to Polycomb group (PcG) proteins of plants and animals. In wild-type Arabidopsis, vernalization results in the stable reduction of the levels of the floral repressor FLC. In vrn2 mutants, FLC expression is downregulated normally in response to vernalization, but instead of remaining low, FLC mRNA levels increase when plants are returned to normal temperatures. VRN2 maintains FLC repression after a cold treatment, serving as a mechanism for the cellular memory of vernalization. Required for complete repression of FLC. Required for the methylation of histone H3
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    Genomic context

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    See VRN2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Sequence:
    Chromosome: 4; NC_003075.7 (9476069..9479878)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2. Gibbs DJ, et al. Nat Commun, 2018 Dec 21. PMID 30575749, Free PMC Article
    2. The VERNALIZATION 2 gene mediates the epigenetic regulation of vernalization in Arabidopsis. Gendall AR, et al. Cell, 2001 Nov 16. PMID 11719192
    3. The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development. Labandera AM, et al. New Phytol, 2021 Jan. PMID 32043277, Free PMC Article
    4. Arabidopsis mutants showing an altered response to vernalization. Chandler J, et al. Plant J, 1996 Oct. PMID 8998499
    5. The Arabidopsis GAGA-Binding Factor BASIC PENTACYSTEINE6 Recruits the POLYCOMB-REPRESSIVE COMPLEX1 Component LIKE HETEROCHROMATIN PROTEIN1 to GAGA DNA Motifs. Hecker A, et al. Plant Physiol, 2015 Jul. PMID 26025051, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.
      Title: The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.
    2. oxygen-sensitive N-terminal degron that promotes degradation via the N-end rule pathway arose early during angiosperm evolution via gene duplication and N-terminal truncation
      Title: Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117787.4
    NM_202834.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic programming in the endosperm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within vernalization response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    VEFS-Box of polycomb protein
    NP_567517.1
    • REDUCED VERNALIZATION RESPONSE 2 (VRN2); CONTAINS InterPro DOMAIN/s: Polycomb protein, VEFS-Box (InterPro:IPR019135); BEST Arabidopsis thaliana protein match is: VEFS-Box of polycomb protein (TAIR:AT5G51230.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974563.1
    • REDUCED VERNALIZATION RESPONSE 2 (VRN2); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: response to cold, regulation of gene expression by genetic imprinting, vernalization response; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Polycomb protein, VEFS-Box (InterPro:IPR019135); BEST Arabidopsis thaliana protein match is: VEFS-Box of polycomb protein (TAIR:AT5G51230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9476069..9479878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117787.4 → NP_567517.1  VEFS-Box of polycomb protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23524, O23525, Q8W5B1, Q8W5B2, Q94CF5
      UniProtKB/TrEMBL
      A0A178UYF6
      Conserved Domains (1) summary
      pfam09733
      Location:250 → 387
      VEFS-Box; VEFS-Box of polycomb protein

    2. NM_202834.2 → NP_974563.1  VEFS-Box of polycomb protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FQ61, F4JMM5
      Conserved Domains (1) summary
      pfam09733
      Location:190 → 327
      VEFS-Box; VEFS-Box of polycomb protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W5B1.2

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