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    Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfm2provided by RGD
    Official Full Name
    GTP dependent ribosome recycling factor mitochondrial 2provided by RGD
    Primary source
    RGD:1309854
    See related
    EnsemblRapid:ENSRNOG00000025285 AllianceGenome:RGD:1309854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309854
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 138.5), Adrenal (RPKM 136.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gfm2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (30184063..30222811)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (28449452..28488200)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27949195..27984045)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 pseudogene Neighboring gene family with sequence similarity 169, member A Neighboring gene NSA2 ribosome biogenesis factor Neighboring gene hexosaminidase subunit beta Neighboring gene uncharacterized LOC120100676 Neighboring gene ectodermal-neural cortex 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Tsuboi M, et al. Mol Cell, 2009 Aug 28. PMID 19716793
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in mitochondrial translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome-releasing factor 2, mitochondrial
    Names
    EF-G2mt
    G elongation factor, mitochondrial 2
    RRF2mt
    elongation factor G 2, mitochondrial
    mEF-G 2
    NP_001094135.1
    XP_006231892.1
    XP_017446189.1
    XP_063137561.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100665.1 → NP_001094135.1  ribosome-releasing factor 2, mitochondrial

      See identical proteins and their annotated locations for NP_001094135.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5BJP6
      UniProtKB/TrEMBL
      A0A0G2K1R1
      Related
      ENSRNOP00000043087.5, ENSRNOT00000052072.6
      Conserved Domains (6) summary
      cd01886
      Location:72 → 352
      EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed
      cd01693
      Location:561 → 679
      mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
      cd03713
      Location:684 → 761
      EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
      cd04092
      Location:367 → 448
      mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
      cd16262
      Location:485 → 560
      EFG_III; Domain III of Elongation Factor G (EFG)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      30184063..30222811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590700.2 → XP_017446189.1  ribosome-releasing factor 2, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q5BJP6
      UniProtKB/TrEMBL
      A0A8I6A4R7
      Related
      ENSRNOP00000086144.1, ENSRNOT00000113513.2

    2. XM_063281491.1 → XP_063137561.1  ribosome-releasing factor 2, mitochondrial isoform X3

      Related
      ENSRNOP00000103345.1, ENSRNOT00000166369.1

    3. XM_006231830.5 → XP_006231892.1  ribosome-releasing factor 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006231892.1

      UniProtKB/Swiss-Prot
      Q5BJP6
      UniProtKB/TrEMBL
      A0A0G2K1R1
      Related
      ENSRNOP00000071947.1, ENSRNOT00000080551.3
      Conserved Domains (6) summary
      cd01886
      Location:72 → 352
      EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed
      cd01693
      Location:561 → 679
      mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
      cd03713
      Location:684 → 761
      EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
      cd04092
      Location:367 → 448
      mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
      cd16262
      Location:485 → 560
      EFG_III; Domain III of Elongation Factor G (EFG)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJP6.2 GenPept UniProtKB/Swiss-Prot:Q5BJP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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