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    Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnph2provided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H2provided by RGD
    Primary source
    RGD:1549784
    See related
    EnsemblRapid:ENSRNOG00000011661 AllianceGenome:RGD:1549784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrph2
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual developmental disorder bain type. Orthologous to human HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 320.1), Brain (RPKM 312.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnph2 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102074175..102080115)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97780890..97786846)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105417603..105423531)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 2 Neighboring gene armadillo repeat containing, X-linked 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2. Grammatikakis I, et al. Cell Rep, 2016 May 3. PMID 27117401, Free PMC Article
    2. hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mauger DM, et al. Mol Cell Biol, 2008 Sep. PMID 18573884, Free PMC Article
    3. Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology. Li KW, et al. J Biol Chem, 2004 Jan 9. PMID 14532281
    4. Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Maggi LB Jr, et al. Mol Cell Biol, 2008 Dec. PMID 18809582, Free PMC Article
    5. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H2
    Names
    heterogeneous nuclear ribonucleoprotein H'
    heterogeneous nuclear ribonucleoprotein H2 (H')
    hnRNP H'
    hnRNP H2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014019.1 → NP_001014041.1  heterogeneous nuclear ribonucleoprotein H2

      See identical proteins and their annotated locations for NP_001014041.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079240
      UniProtKB/Swiss-Prot
      Q6AY09
      UniProtKB/TrEMBL
      A6IVG4, G3V9Q3
      Related
      ENSRNOP00000015518.3, ENSRNOT00000015518.6
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      102074175..102080115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279968.1 → XP_063136038.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY09
      UniProtKB/TrEMBL
      A6IVG4, G3V9Q3

    2. XM_006257220.5 → XP_006257282.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

      See identical proteins and their annotated locations for XP_006257282.1

      UniProtKB/Swiss-Prot
      Q6AY09
      UniProtKB/TrEMBL
      A6IVG4, G3V9Q3
      Related
      ENSRNOP00000096745.1, ENSRNOT00000119849.2
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    3. XM_006257219.5 → XP_006257281.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

      See identical proteins and their annotated locations for XP_006257281.1

      UniProtKB/Swiss-Prot
      Q6AY09
      UniProtKB/TrEMBL
      A6IVG4, G3V9Q3
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    4. XM_006257221.4 → XP_006257283.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

      See identical proteins and their annotated locations for XP_006257283.1

      UniProtKB/Swiss-Prot
      Q6AY09
      UniProtKB/TrEMBL
      A6IVG4, G3V9Q3
      Conserved Domains (4) summary
      pfam08080
      Location:257 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY09.1 GenPept UniProtKB/Swiss-Prot:Q6AY09

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