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    Usp7 ubiquitin specific peptidase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360471, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp7provided by RGD
    Official Full Name
    ubiquitin specific peptidase 7provided by RGD
    Primary source
    RGD:1306915
    See related
    EnsemblRapid:ENSRNOG00000025496 AllianceGenome:RGD:1306915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hausp
    Summary
    Enables cysteine-type deubiquitinase activity and identical protein binding activity. Involved in positive regulation of apoptotic process; protein deubiquitination; and regulation of protein stability. Predicted to be located in XY body and cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in PML body and cytosol. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 367.9), Thymus (RPKM 342.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Usp7 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (7335508..7432018)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (6880684..6925355)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (6930462..7019910)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HUWE1 associated protein modifying stress responses Neighboring gene uncharacterized LOC102546403 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene Neighboring gene LITAF domain containing Neighboring gene calcium regulated heat stable protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity  
    enables K48-linked deubiquitinase activity  
    enables K48-linked deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity PubMed 
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables deubiquitinase activity  
    enables deubiquitinase activity  
    enables identical protein binding PubMed 
    enables p53 binding  
    enables p53 binding  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in DNA alkylation repair  
    involved_in DNA alkylation repair  
    involved_in DNA alkylation repair  
    involved_in monoubiquitinated protein deubiquitination  
    acts_upstream_of_or_within monoubiquitinated protein deubiquitination  
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in protein deubiquitination PubMed 
    involved_in protein deubiquitination  
    involved_in protein deubiquitination  
    involved_in protein deubiquitination  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in proteolysis  
    involved_in regulation of DNA-binding transcription factor activity  
    involved_in regulation of DNA-binding transcription factor activity  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of establishment of protein localization to telomere  
    involved_in regulation of establishment of protein localization to telomere  
    involved_in regulation of protein stability  
    involved_in regulation of protein stability PubMed 
    involved_in regulation of protein stability  
    involved_in regulation of retrograde transport, endosome to Golgi  
    involved_in regulation of retrograde transport, endosome to Golgi  
    involved_in rhythmic process  
    involved_in symbiont-mediated disruption of host cell PML body  
    involved_in symbiont-mediated disruption of host cell PML body  
    involved_in transcription elongation-coupled chromatin remodeling  
    involved_in transcription-coupled nucleotide-excision repair  
    involved_in transcription-coupled nucleotide-excision repair  
    involved_in transcription-coupled nucleotide-excision repair  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    located_in PML body  
    is_active_in PML body  
    located_in XY body  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 7
    Names
    deubiquitinating enzyme 7
    herpes-virus-associated ubiquitin-specific protease
    herpesvirus-associated ubiquitin-specific protease
    rHAUSP
    ubiquitin specific peptidase 7 (herpes virus-associated)
    ubiquitin specific protease 7 (herpes virus-associated)
    ubiquitin thioesterase 7
    ubiquitin-specific-processing protease 7
    NP_001019961.2
    XP_006245819.1
    XP_063125353.1
    XP_063125354.1
    XP_063125355.1
    XP_063125356.1
    XP_063125357.1
    XP_063125358.1
    XP_063125359.1
    XP_063125360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024790.2NP_001019961.2  ubiquitin carboxyl-terminal hydrolase 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4VSI4
      UniProtKB/TrEMBL
      A0A8I6AP58
      Related
      ENSRNOP00000096267.1, ENSRNOT00000100242.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      7335508..7432018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269283.1XP_063125353.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSA1
    2. XM_063269286.1XP_063125356.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSA1, A0A8I5ZZJ8
    3. XM_063269285.1XP_063125355.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSA1, A0A8I5ZZJ8
      Related
      ENSRNOP00000083535.1, ENSRNOT00000117646.2
    4. XM_063269284.1XP_063125354.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSA1
    5. XM_063269287.1XP_063125357.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

      UniProtKB/Swiss-Prot
      Q4VSI4
    6. XM_063269288.1XP_063125358.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSA1
    7. XM_006245757.5XP_006245819.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZSA1, A0A8I6AKU3
      Related
      ENSRNOP00000093874.1, ENSRNOT00000094143.2
      Conserved Domains (5) summary
      COG5077
      Location:391084
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:196507
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:51186
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:604849
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:8591070
      USP7_C2; Ubiquitin-specific protease C-terminal
    8. XM_063269289.1XP_063125359.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A6B9
    9. XM_063269290.1XP_063125360.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X7

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