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    Ect2 epithelial cell transforming 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361921, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ect2provided by RGD
    Official Full Name
    epithelial cell transforming 2provided by RGD
    Primary source
    RGD:1308524
    See related
    EnsemblRapid:ENSRNOG00000024365 AllianceGenome:RGD:1308524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; bicellular tight junction assembly; and regulation of cell cycle process. Predicted to act upstream of or within cell morphogenesis. Predicted to be located in several cellular components, including bicellular tight junction; cleavage furrow; and midbody. Predicted to be part of centralspindlin complex. Predicted to be active in cell cortex and nucleus. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 141.4), Spleen (RPKM 98.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ect2 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (111904522..111966786, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (109975813..110037911, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (112769385..112831476, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 16 Neighboring gene uncharacterized LOC102555118 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485890 Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene mitochondrial ribosomal protein L54, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables protein homodimerization activity  
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity  
    involved_in activation of protein kinase activity  
    involved_in bicellular tight junction assembly  
    acts_upstream_of_or_within cell morphogenesis  
    involved_in cellular response to calcium ion  
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to ionizing radiation  
    involved_in intracellular signal transduction  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in nervous system development  
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of mitotic cytokinetic process  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of protein import into nucleus  
    involved_in protein homooligomerization  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly  
    involved_in regulation of protein kinase activity  
    Component Evidence Code Pubs
    located_in bicellular tight junction  
    is_active_in cell cortex  
    located_in cell-cell junction  
    part_of centralspindlin complex  
    located_in cleavage furrow  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in midbody  
    located_in mitotic spindle  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    protein ECT2
    Names
    ect2 oncogene
    epithelial cell transforming sequence 2 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108547.3NP_001102017.2  protein ECT2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GJ38, D3ZUD0
      Related
      ENSRNOP00000018055.7, ENSRNOT00000018055.10
      Conserved Domains (4) summary
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      111904522..111966786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282047.1XP_063138117.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJ38
    2. XM_063282043.1XP_063138113.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ38, D3ZUD0
    3. XM_063282046.1XP_063138116.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ38, D3ZUD0
    4. XM_063282044.1XP_063138114.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ38, D3ZUD0
    5. XM_063282050.1XP_063138120.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJ38
    6. XM_063282048.1XP_063138118.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJ38
      Related
      ENSRNOP00000096182.2, ENSRNOT00000092855.3
    7. XM_063282049.1XP_063138119.1  protein ECT2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJ38
    8. XM_063282045.1XP_063138115.1  protein ECT2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ38, D3ZUD0

    RNA

    1. XR_010063624.1 RNA Sequence

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