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    LUP2 lupeol synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844236, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LUP2
    Official Full Name
    lupeol synthase 2
    Primary source
    TAIR:AT1G78960
    Locus tag
    AT1G78960
    See related
    Araport:AT1G78960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLUP2; lupeol synthase 2; YUP8H12R.43; YUP8H12R_43
    Summary
    Encodes a multifunctional 2-3-oxidosqualene (OS)-triterpene cyclase that can cyclize OS into lupeol, alpha- and beta-amyrin.
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    Genomic context

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    See LUP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (29696394..29701439)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Terpenoid cyclases family protein Neighboring gene camelliol C synthase 1 Neighboring gene lupeol synthase 1 Neighboring gene STRUBBELIG-receptor family 5 Neighboring gene HXXXD-type acyl-transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. Herrera JB, et al. Phytochemistry, 1998 Dec. PMID 9883589
    2. Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana. Husselstein-Muller T, et al. Plant Mol Biol, 2001 Jan. PMID 11247608
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001334862.1
    NM_001334863.1
    NM_001334864.1
    NM_106545.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-amyrin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lupeol synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lupeol synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pentacyclic triterpenoid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triterpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lupeol synthase 2
    NP_178017.2
    • lupeol synthase 2 (LUP2); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: Terpenoid cyclases family protein (TAIR:AT1G66960.1); Has 2115 Blast hits to 2006 proteins in 580 species: Archae - 2; Bacteria - 935; Metazoa - 110; Fungi - 239; Plants - 613; Viruses - 0; Other Eukaryotes - 216 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29696394..29701439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334861.1 → NP_001322959.1  lupeol synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64552, Q0WLS2, Q56X57, Q84L74, Q8RWT0
      UniProtKB/TrEMBL
      A0A5S9WVM8, A0A654EQ77

    2. NM_106545.4 → NP_178017.2  lupeol synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178017.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64552, Q0WLS2, Q56X57, Q84L74, Q8RWT0
      UniProtKB/TrEMBL
      A0A5S9WVM8, A0A654EQ77
      Conserved Domains (2) summary
      PLN02993
      Location:1 → 763
      PLN02993; lupeol synthase
      cd02892
      Location:99 → 752
      SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...

    3. NM_001334862.1 → NP_001322960.1  lupeol synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64552, Q0WLS2, Q56X57, Q84L74, Q8RWT0
      UniProtKB/TrEMBL
      A0A5S9WVM8, A0A654EQ77

    4. NM_001334863.1 → NP_001322961.1  lupeol synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGS3, A0A1P8AVI0

    5. NM_001334864.1 → NP_001322958.1  lupeol synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WIF7, A0A1P8AVK7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWT0.1

    Gene LinkOut

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