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    PP5.2 protein phosphatase 5.2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818881, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PP5.2
    Official Full Name
    protein phosphatase 5.2
    Primary source
    TAIR:AT2G42810
    Locus tag
    AT2G42810
    See related
    Araport:AT2G42810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana protein phosphatase 5; AtPP5; F7D19.19; F7D19_19; PAPP5; Phytochrome-Associated Protein Phosphatase 5; PP5; PROTEIN PHOSPHATASE 5; protein phosphatase 5.2
    Summary
    Encodes a phytochrome-specific type 5 serine/threonine protein phosphatase. It dephosphorylates active Pfr-phytochromes. Controls light signal flux by enhancing phytochrome stability and affinity for a signal transducer. The gene is alternately spliced. This variant is an integral membrane protein localized to the ER and nuclear envelope. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones. It also regulates tetrapyrrole biosynthesis through the accumulation of Mg-ProtoIX and acts as a negative regulator of photosynthesis associated nuclear gene expression during chloroplast biogenesis and development.
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    Genomic context

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    See PP5.2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (17811935..17816772, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene citrate synthase 3 Neighboring gene ncRNA Neighboring gene receptor like protein 29 Neighboring gene HVA22-like protein F Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heat-induced chaperone activity of serine/threonine protein phosphatase 5 enhances thermotolerance in Arabidopsis thaliana. Park JH, et al. New Phytol, 2011 Aug. PMID 21564098
    2. The complement of protein phosphatase catalytic subunits encoded in the genome of Arabidopsis. Kerk D, et al. Plant Physiol, 2002 Jun. PMID 12068129, Free PMC Article
    3. Purification of plant protein phosphatase PP7 and evidence for its redox regulation. Andreeva AV, et al. Arch Biochem Biophys, 2001 Dec 1. PMID 11716463
    4. Unraveling the MAX2 Protein Network in Arabidopsis thaliana: Identification of the Protein Phosphatase PAPP5 as a Novel MAX2 Interactor. Struk S, et al. Mol Cell Proteomics, 2021. PMID 33372050, Free PMC Article
    5. PAPP5 is involved in the tetrapyrrole mediated plastid signalling during chloroplast development. Barajas-López Jde D, et al. PLoS One, 2013. PMID 23555952, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unraveling the MAX2 Protein Network in Arabidopsis thaliana: Identification of the Protein Phosphatase PAPP5 as a Novel MAX2 Interactor.
      Title: Unraveling the MAX2 Protein Network in Arabidopsis thaliana: Identification of the Protein Phosphatase PAPP5 as a Novel MAX2 Interactor.
    2. Results suggest that PAPP5 receives an inbalance in the tetrapyrrole biosynthesis through the accumulation of Mg-ProtoIX and acts as a negative regulator of PhANG expression during chloroplast biogenesis and development.
      Title: PAPP5 is involved in the tetrapyrrole mediated plastid signalling during chloroplast development.
    3. AtPP5 performs multiple enzymatic activities that are mediated by conformational changes induced by heat-shock stress.
      Title: Heat-induced chaperone activity of serine/threonine protein phosphatase 5 enhances thermotolerance in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036457.3
    NM_001336994.1
    NM_001336995.1
    NM_001336996.1
    NM_129842.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables tetrapyrrole binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast-nucleus signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleocytoplasmic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within red or far-red light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 5.2
    NP_001031534.1
    • protein phosphatase 5.2 (PP5.2); FUNCTIONS IN: protein binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; INVOLVED IN: response to cadmium ion, nucleocytoplasmic transport, red or far-red light signaling pathway; LOCATED IN: nuclear envelope, integral to endoplasmic reticulum membrane, nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Metallophosphoesterase (InterPro:IPR004843), Protein phosphatase 5 (InterPro:IPR011236), Tetratricopeptide-like helical (InterPro:IPR011990), Serine/threonine phosphatase, PPP5 (InterPro:IPR013235), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: Calcineurin-like metallo-phosphoesterase superfamily protein (TAIR:AT5G27840.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_565985.1
    • PROTEIN PHOSPHATASE 5 (PP5); FUNCTIONS IN: protein binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; INVOLVED IN: response to cadmium ion, nucleocytoplasmic transport, red or far-red light signaling pathway; LOCATED IN: nuclear envelope, integral to endoplasmic reticulum membrane, nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Metallophosphoesterase (InterPro:IPR004843), Tetratricopeptide-like helical (InterPro:IPR011990), Protein phosphatase 5 (InterPro:IPR011236), Serine/threonine phosphatase, PPP5 (InterPro:IPR013235), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 2 (TAIR:AT5G59160.3); Has 25788 Blast hits to 18302 proteins in 1121 species: Archae - 994; Bacteria - 7255; Metazoa - 6041; Fungi - 2745; Plants - 2732; Viruses - 0; Other Eukaryotes - 6021 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17811935..17816772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129842.4 → NP_565985.1  protein phosphatase 5.2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPU7, A0A5S9X6J3
      Conserved Domains (3) summary
      PLN03088
      Location:13 → 162
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:13 → 41
      TPR; TPR repeat [structural motif]
      cd07417
      Location:162 → 477
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain

    2. NM_001336994.1 → NP_001323831.1  protein phosphatase 5.2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AY87, A0A7G2EFS2
      Conserved Domains (3) summary
      PLN03088
      Location:13 → 155
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:13 → 41
      TPR; TPR repeat [structural motif]
      cd07417
      Location:215 → 530
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain

    3. NM_001036457.3 → NP_001031534.1  protein phosphatase 5.2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031534.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56X87, Q84XU2, Q8RXU0, Q8W581, Q9SJH5
      Conserved Domains (8) summary
      smart00028
      Location:13 → 46
      TPR; Tetratricopeptide repeats
      smart00156
      Location:244 → 520
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      sd00006
      Location:13 → 41
      TPR; TPR repeat [structural motif]
      cd07417
      Location:216 → 531
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
      pfam00515
      Location:81 → 114
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:12 → 77
      TPR_11; TPR repeat
      pfam13431
      Location:35 → 68
      TPR_17; Tetratricopeptide repeat
      pfam13432
      Location:53 → 115
      TPR_16; Tetratricopeptide repeat

    4. NM_001336995.1 → NP_001323832.1  protein phosphatase 5.2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPU7, A0A5S9X6J3
      Conserved Domains (3) summary
      PLN03088
      Location:13 → 162
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:13 → 41
      TPR; TPR repeat [structural motif]
      cd07417
      Location:162 → 477
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain

    5. NM_001336996.1 → NP_001323833.1  protein phosphatase 5.2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VPU7, A0A5S9X6J3
      Conserved Domains (3) summary
      PLN03088
      Location:13 → 162
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:13 → 41
      TPR; TPR repeat [structural motif]
      cd07417
      Location:162 → 477
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84XU2.1

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