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    GRF3 growth-regulating factor 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818213, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRF3
    Official Full Name
    growth-regulating factor 3
    Primary source
    TAIR:AT2G36400
    Locus tag
    AT2G36400
    See related
    Araport:AT2G36400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGRF3; F1O11.3; F1O11_3; growth-regulating factor 3
    Summary
    Growth regulating factor encoding transcription activator. One of the nine members of a GRF gene family, containing nuclear targeting domain. Mutants result in smaller leaves indicating the role of the gene in leaf development. Expressed in root, shoot and flower.
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    Genomic context

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    See GRF3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (15270088..15273115, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pleiotropic drug resistance 6 Neighboring gene starch branching enzyme 2.1 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene transcriptional activator (DUF662)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GROWTH-REGULATING FACTORS Interact with DELLAs and Regulate Growth in Cold Stress. Lantzouni O, et al. Plant Cell, 2020 Apr. PMID 32060178, Free PMC Article
    2. MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots. Rodriguez RE, et al. Plant Cell, 2015 Dec. PMID 26645252, Free PMC Article
    3. The Arabidopsis microRNA396-GRF1/GRF3 regulatory module acts as a developmental regulator in the reprogramming of root cells during cyst nematode infection. Hewezi T, et al. Plant Physiol, 2012 May. PMID 22419826, Free PMC Article
    4. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Kim JH, et al. Plant J, 2003 Oct. PMID 12974814
    5. Molecular mechanism of microRNA396 mediating pistil development in Arabidopsis. Liang G, et al. Plant Physiol, 2014 Jan. PMID 24285851, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRF1 and GRF3 are posttranscriptionally regulated by miR396 during nematode infection.
      Title: The Arabidopsis microRNA396-GRF1/GRF3 regulatory module acts as a developmental regulator in the reprogramming of root cells during cyst nematode infection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129197.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gibberellin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth-regulating factor 3
    NP_181181.1
    • growth-regulating factor 3 (GRF3); CONTAINS InterPro DOMAIN/s: Glutamine-Leucine-Glutamine, QLQ (InterPro:IPR014978), WRC (InterPro:IPR014977); BEST Arabidopsis thaliana protein match is: growth-regulating factor 4 (TAIR:AT3G52910.1); Has 1366 Blast hits to 762 proteins in 75 species: Archae - 0; Bacteria - 63; Metazoa - 212; Fungi - 25; Plants - 542; Viruses - 0; Other Eukaryotes - 524 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15270088..15273115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129197.4 → NP_181181.1  growth-regulating factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181181.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GYS6, Q9SJR5
      UniProtKB/TrEMBL
      A0A178VSH7, A0A5S9X4G6, A0A654FA07
      Conserved Domains (2) summary
      pfam08879
      Location:145 → 186
      WRC
      pfam08880
      Location:77 → 110
      QLQ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJR5.1

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