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    Gimap5 GTPase, IMAP family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246774, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gimap5provided by RGD
    Official Full Name
    GTPase, IMAP family member 5provided by RGD
    Primary source
    RGD:628871
    See related
    EnsemblRapid:ENSRNOG00000008416 AllianceGenome:RGD:628871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    lyp; IAN4; Ian5; Ian4l1
    Summary
    Predicted to enable GTP binding activity. Involved in several processes, including mononuclear cell differentiation; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Predicted to be located in lysosomal membrane; mitochondrion; and multivesicular body membrane. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to human GIMAP5 (GTPase, IMAP family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 123.9), Lung (RPKM 62.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Gimap5 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79025151..79031917)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77693417..77701025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78377228..78386683)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 7 Neighboring gene GTPase, IMAP family member 1 Neighboring gene transmembrane protein 176B Neighboring gene transmembrane protein 176A Neighboring gene amine oxidase, copper containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding  
    Process Evidence Code Pubs
    involved_in T cell differentiation PubMed 
    involved_in T cell homeostasis PubMed 
    involved_in myeloid dendritic cell differentiation PubMed 
    involved_in negative regulation of T cell activation PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of lipid catabolic process PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process PubMed 
    involved_in negative regulation of type II interferon production PubMed 
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation PubMed 
    involved_in positive regulation of calcium ion transport into cytosol PubMed 
    involved_in positive regulation of gamma-delta T cell differentiation PubMed 
    involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin PubMed 
    involved_in positive regulation of membrane potential PubMed 
    involved_in positive regulation of natural killer cell cytokine production PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity PubMed 
    involved_in regulation of mitochondrial membrane permeability PubMed 
    involved_in temperature homeostasis PubMed 
    Component Evidence Code Pubs
    located_in lysosomal membrane  
    located_in mitochondrion  
    located_in multivesicular body membrane  

    General protein information

    Preferred Names
    GTPase IMAP family member 5
    Names
    IAN-4
    immune associated nucleotide 4 like 1
    immunity-associated nucleotide 4 protein
    immunity-associated nucleotide 4-like 1 protein
    lymphopenia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033913.1NP_001029085.1  GTPase IMAP family member 5 isoform 1

      See identical proteins and their annotated locations for NP_001029085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AY550018
      UniProtKB/Swiss-Prot
      Q5YEJ2, Q5YEJ3, Q8K3L6, Q8K3L7
      UniProtKB/TrEMBL
      A6K0I1
      Related
      ENSRNOP00000072663.2, ENSRNOT00000084927.3
      Conserved Domains (2) summary
      cd01852
      Location:45245
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl21455
      Location:1466
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_145680.3NP_663713.1  GTPase IMAP family member 5 isoform 2

      See identical proteins and their annotated locations for NP_663713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, that results in the use of an upstream start codon. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AY055776, AY550018
      UniProtKB/TrEMBL
      Q0R3W7
      Conserved Domains (1) summary
      cd01852
      Location:27227
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      79025151..79031917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236458.5XP_006236520.1  GTPase IMAP family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006236520.1

      UniProtKB/TrEMBL
      Q0R3W7
      Conserved Domains (1) summary
      cd01852
      Location:27227
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
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