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    Lrrfip2 LRR binding FLII interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301035, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrrfip2provided by RGD
    Official Full Name
    LRR binding FLII interacting protein 2provided by RGD
    Primary source
    RGD:1306234
    See related
    EnsemblRapid:ENSRNOG00000021047 AllianceGenome:RGD:1306234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable LRR domain binding activity. Predicted to be involved in Wnt signaling pathway and regulation of DNA-templated transcription. Predicted to act upstream of or within regulation of gene expression and toll-like receptor signaling pathway. Orthologous to human LRRFIP2 (LRR binding FLII interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 310.8), Testes (RPKM 188.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrrfip2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119969908..120071270)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (111091453..111193947)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119381666..119484125)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094383 Neighboring gene uncharacterized LOC102552504 Neighboring gene mutL homolog 1 Neighboring gene EPM2A interacting protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General protein information

    Preferred Names
    leucine-rich repeat flightless-interacting protein 2
    Names
    LRR FLII-interacting protein 2
    leucine rich repeat (in FLII) interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024761.1NP_001019932.1  leucine-rich repeat flightless-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001019932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC097955
      UniProtKB/Swiss-Prot
      Q4V7E8
      UniProtKB/TrEMBL
      A0A8I5ZMY2
      Conserved Domains (2) summary
      pfam09738
      Location:47362
      LRRFIP; LRRFIP family
      pfam11932
      Location:378437
      DUF3450; Protein of unknown function (DUF3450)
    2. NM_001395739.1NP_001382668.1  leucine-rich repeat flightless-interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZMY2
      Related
      ENSRNOP00000079448.2, ENSRNOT00000100197.2
      Conserved Domains (2) summary
      pfam09738
      Location:47349
      LRRFIP; LRRFIP family
      pfam11932
      Location:365424
      DUF3450; Protein of unknown function (DUF3450)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119969908..120071270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766619.3XP_008764841.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764841.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463585
      MreC; rod shape-determining protein MreC
    2. XM_063265276.1XP_063121346.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

      UniProtKB/TrEMBL
      A6I3J0
    3. XM_063265279.1XP_063121349.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

      UniProtKB/TrEMBL
      A6I3J0
    4. XM_063265288.1XP_063121358.1  leucine-rich repeat flightless-interacting protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A8I5ZMY2
    5. XM_063265281.1XP_063121351.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

      UniProtKB/TrEMBL
      A6I3J0
    6. XM_063265287.1XP_063121357.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

    7. XM_063265285.1XP_063121355.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

    8. XM_063265292.1XP_063121362.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZMY2, A0A8I5ZQP7
    9. XM_063265291.1XP_063121361.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

    10. XM_008766616.4XP_008764838.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764838.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Related
      ENSRNOP00000082163.1, ENSRNOT00000108084.2
      Conserved Domains (2) summary
      pfam09738
      Location:319673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463585
      MreC; rod shape-determining protein MreC
    11. XM_008766625.4XP_008764847.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (3) summary
      pfam09738
      Location:319639
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cd16269
      Location:493504
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:369504
      GBP_C; Guanylate-binding protein, C-terminal domain
    12. XM_017595600.3XP_017451089.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLX7
    13. XM_006243939.4XP_006244001.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AUZ7, A0A8I6GLX7
      Related
      ENSRNOP00000097455.1, ENSRNOT00000112179.2
      Conserved Domains (2) summary
      pfam09738
      Location:319608
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam17031
      Location:375431
      DUF5101; Domain of unknown function (DUF5101)
    14. XM_008766623.3XP_008764845.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319649
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:439561
      MreC; rod shape-determining protein MreC
    15. XM_039081260.2XP_038937188.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319615
      LRRFIP; LRRFIP family
      pfam11932
      Location:631690
      DUF3450; Protein of unknown function (DUF3450)
    16. XM_039081259.2XP_038937187.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319618
      LRRFIP; LRRFIP family
      pfam11932
      Location:634693
      DUF3450; Protein of unknown function (DUF3450)
    17. XM_063265272.1XP_063121342.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6GLX7
    18. XM_008766624.4XP_008764846.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:289643
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:433555
      MreC; rod shape-determining protein MreC
    19. XM_039081261.2XP_038937189.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:289612
      LRRFIP; LRRFIP family
      pfam11932
      Location:628687
      DUF3450; Protein of unknown function (DUF3450)
    20. XM_039081271.2XP_038937199.1  leucine-rich repeat flightless-interacting protein 2 isoform X13

      Conserved Domains (2) summary
      pfam09738
      Location:138492
      LRRFIP; LRRFIP family
      pfam11932
      Location:508567
      DUF3450; Protein of unknown function (DUF3450)
    21. XM_063265277.1XP_063121347.1  leucine-rich repeat flightless-interacting protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZMY2
    22. XM_063265273.1XP_063121343.1  leucine-rich repeat flightless-interacting protein 2 isoform X15

    23. XM_063265280.1XP_063121350.1  leucine-rich repeat flightless-interacting protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZMY2
    24. XM_039081272.2XP_038937200.1  leucine-rich repeat flightless-interacting protein 2 isoform X14

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47469
      LRRFIP; LRRFIP family
      pfam11932
      Location:485544
      DUF3450; Protein of unknown function (DUF3450)
    25. XM_063265275.1XP_063121345.1  leucine-rich repeat flightless-interacting protein 2 isoform X18

      UniProtKB/TrEMBL
      A6I3J0
    26. XM_063265274.1XP_063121344.1  leucine-rich repeat flightless-interacting protein 2 isoform X17

      UniProtKB/TrEMBL
      A6I3J0
    27. XM_063265278.1XP_063121348.1  leucine-rich repeat flightless-interacting protein 2 isoform X22

      UniProtKB/TrEMBL
      A6I3J0
    28. XM_008766626.3XP_008764848.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A2V6
      Related
      ENSRNOP00000079352.2, ENSRNOT00000119180.2
      Conserved Domains (2) summary
      pfam09738
      Location:279633
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:423545
      MreC; rod shape-determining protein MreC
    29. XM_039081273.2XP_038937201.1  leucine-rich repeat flightless-interacting protein 2 isoform X16

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47452
      LRRFIP; LRRFIP family
      pfam11932
      Location:468527
      DUF3450; Protein of unknown function (DUF3450)
    30. XM_063265282.1XP_063121352.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A8I5ZMY2, A0A8I6AJ95
    31. XM_063265284.1XP_063121354.1  leucine-rich repeat flightless-interacting protein 2 isoform X29

      UniProtKB/TrEMBL
      A0A8I5ZMY2
    32. XM_039081277.2XP_038937205.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47429
      LRRFIP; LRRFIP family
      pfam11932
      Location:445504
      DUF3450; Protein of unknown function (DUF3450)
    33. XM_008766628.4XP_008764850.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A2V6
      Related
      ENSRNOP00000091298.2, ENSRNOT00000099949.2
      Conserved Domains (2) summary
      pfam09738
      Location:264618
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:408530
      MreC; rod shape-determining protein MreC
    34. XM_039081281.2XP_038937209.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47414
      LRRFIP; LRRFIP family
      pfam11932
      Location:430489
      DUF3450; Protein of unknown function (DUF3450)
    35. XM_063265283.1XP_063121353.1  leucine-rich repeat flightless-interacting protein 2 isoform X27

      UniProtKB/TrEMBL
      A6I3J0
    36. XM_039081283.2XP_038937211.1  leucine-rich repeat flightless-interacting protein 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I6A6N0, A6I3J0
    37. XM_039081282.2XP_038937210.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

      UniProtKB/TrEMBL
      A6I3J0
      Conserved Domains (2) summary
      pfam09738
      Location:47390
      LRRFIP; LRRFIP family
      pfam11932
      Location:406465
      DUF3450; Protein of unknown function (DUF3450)
    38. XM_063265286.1XP_063121356.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

    39. XM_039081285.2XP_038937213.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

    40. XM_006243960.3XP_006244022.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZMY2, A0A8I5ZQP7
      Conserved Domains (2) summary
      pfam09738
      Location:47325
      LRRFIP; LRRFIP family
      pfam11932
      Location:341400
      DUF3450; Protein of unknown function (DUF3450)
    41. XM_039081286.2XP_038937214.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

      Conserved Domains (2) summary
      pfam09738
      Location:52336
      LRRFIP; LRRFIP family
      pfam11932
      Location:352411
      DUF3450; Protein of unknown function (DUF3450)
    42. XM_063265296.1XP_063121366.1  leucine-rich repeat flightless-interacting protein 2 isoform X39

    43. XM_063265295.1XP_063121365.1  leucine-rich repeat flightless-interacting protein 2 isoform X38

    44. XM_008766618.4XP_008764840.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764840.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463585
      MreC; rod shape-determining protein MreC
    45. XM_008766617.4XP_008764839.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764839.1

      UniProtKB/TrEMBL
      A0A8I5ZUL9, A0A8I6GLX7
      Conserved Domains (2) summary
      pfam09738
      Location:319673
      DUF2051; Double stranded RNA binding protein (DUF2051)
      cl19252
      Location:463585
      MreC; rod shape-determining protein MreC
    46. XM_039081284.2XP_038937212.1  leucine-rich repeat flightless-interacting protein 2 isoform X28

      Conserved Domains (2) summary
      pfam09738
      Location:10364
      LRRFIP; LRRFIP family
      pfam11932
      Location:380439
      DUF3450; Protein of unknown function (DUF3450)
    47. XM_063265290.1XP_063121360.1  leucine-rich repeat flightless-interacting protein 2 isoform X33

    48. XM_063265293.1XP_063121363.1  leucine-rich repeat flightless-interacting protein 2 isoform X36

    49. XM_063265294.1XP_063121364.1  leucine-rich repeat flightless-interacting protein 2 isoform X37

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