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    Cdk2 cyclin dependent kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362817, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk2provided by RGD
    Official Full Name
    cyclin dependent kinase 2provided by RGD
    Primary source
    RGD:70486
    See related
    EnsemblRapid:ENSRNOG00000006469 AllianceGenome:RGD:70486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including cellular response to insulin stimulus; response to cAMP; and response to estradiol. Predicted to be located in several cellular components, including centrosome; chromosome; and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Used to study membranoproliferative glomerulonephritis. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 69.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdk2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1714392..1721964, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1129878..1137431, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3124953..3132533, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sulfite oxidase Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC120093528 Neighboring gene premelanosome protein Neighboring gene diacylglycerol kinase, alpha Neighboring gene roadblock domain containing 3, pseudogene 1 Neighboring gene PYM homolog 1, exon junction complex associated factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables cyclin binding  
    enables cyclin binding  
    enables cyclin binding PubMed 
    enables cyclin binding  
    enables cyclin-dependent protein kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables histone kinase activity  
    contributes_to histone kinase activity  
    enables kinase activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 50
    Process Evidence Code Pubs
    involved_in DNA damage response PubMed 
    involved_in DNA repair  
    involved_in DNA synthesis involved in mitotic DNA replication PubMed 
    involved_in DNA-templated transcription  
    acts_upstream_of DNA-templated transcription  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle  
    involved_in Ras protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in cell division  
    involved_in cellular response to insulin stimulus PubMed 
    involved_in centriole replication  
    involved_in centriole replication  
    involved_in chromatin remodeling  
    involved_in lens development in camera-type eye PubMed 
    involved_in liver regeneration PubMed 
    involved_in meiotic cell cycle  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of DNA-templated DNA replication initiation  
    acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of heterochromatin formation  
    involved_in positive regulation of heterochromatin formation  
    involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation  
    involved_in post-translational protein modification  
    involved_in post-translational protein modification  
    involved_in potassium ion transport  
    acts_upstream_of_or_within potassium ion transport  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of G2/M transition of mitotic cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of gene expression  
    involved_in response to cAMP PubMed 
    involved_in response to cadmium ion PubMed 
    involved_in response to electrical stimulus PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    involved_in telomere maintenance in response to DNA damage  
    involved_in telomere maintenance in response to DNA damage  
    Items 1 - 25 of 50
    Items 1 - 20 of 36
    Component Evidence Code Pubs
    located_in Cajal body  
    located_in Cajal body  
    located_in X chromosome  
    located_in X chromosome  
    located_in Y chromosome  
    located_in Y chromosome  
    located_in centrosome  
    located_in centrosome  
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in condensed chromosome  
    located_in condensed chromosome  
    part_of cyclin A1-CDK2 complex  
    part_of cyclin A1-CDK2 complex  
    part_of cyclin A2-CDK2 complex  
    part_of cyclin A2-CDK2 complex  
    part_of cyclin E1-CDK2 complex  
    part_of cyclin E1-CDK2 complex  
    part_of cyclin E2-CDK2 complex  
    part_of cyclin E2-CDK2 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in endosome  
    located_in endosome  
    located_in male germ cell nucleus  
    located_in male germ cell nucleus  
    located_in nuclear envelope  
    located_in nuclear envelope  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex  
    part_of transcription regulator complex  
    Items 1 - 20 of 36

    General protein information

    Preferred Names
    cyclin-dependent kinase 2
    Names
    cell division protein kinase 2
    cyclin dependent kinase 2-alpha
    NP_955795.1
    XP_006240840.1
    XP_038935306.1
    XP_038935307.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199501.2NP_955795.1  cyclin-dependent kinase 2

      See identical proteins and their annotated locations for NP_955795.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O09136, Q63699
      UniProtKB/TrEMBL
      F6PTK8, Q6P751
      Related
      ENSRNOP00000032191.3, ENSRNOT00000031963.5
      Conserved Domains (1) summary
      cd07860
      Location:3286
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1714392..1721964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240778.3XP_006240840.1  cyclin-dependent kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006240840.1

      UniProtKB/Swiss-Prot
      O09136, Q63699
      UniProtKB/TrEMBL
      A0A8I6AHN8
      Related
      ENSRNOP00000094402.1, ENSRNOT00000101553.2
      Conserved Domains (1) summary
      cd07860
      Location:3334
      STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
    2. XM_039079378.2XP_038935306.1  cyclin-dependent kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1244
      PKc_like; Protein Kinases, catalytic domain
    3. XM_039079379.2XP_038935307.1  cyclin-dependent kinase 2 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1196
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_010052990.1 RNA Sequence

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