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    Rasal2 RAS protein activator like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasal2provided by RGD
    Official Full Name
    RAS protein activator like 2provided by RGD
    Primary source
    RGD:1307566
    See related
    EnsemblRapid:ENSRNOG00000004917 AllianceGenome:RGD:1307566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including adipose tissue development; response to dietary excess; and response to glucose. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 116.9), Lung (RPKM 95.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasal2 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (71808740..72102723, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (69279882..69569161, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (74770557..75059298, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 1 Neighboring gene Ral GEF with PH domain and SH3 binding motif 2 Neighboring gene C-type lectin domain containing 20A Neighboring gene testis expressed 35 Neighboring gene serine and arginine rich splicing factor 6, pseudogene 2 Neighboring gene uncharacterized LOC134481517 Neighboring gene RIKEN cDNA 2810025M15 gene like Neighboring gene uncharacterized LOC134481518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein activation cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein nGAP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401195.1 → NP_001388124.1  ras GTPase-activating protein nGAP isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZWM6, A0A8I6AI87

    2. NM_001401196.1 → NP_001388125.1  ras GTPase-activating protein nGAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AI87
      Related
      ENSRNOP00000089478.2, ENSRNOT00000102068.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      71808740..72102723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598813.3 → XP_017454302.1  ras GTPase-activating protein nGAP isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Related
      ENSRNOP00000092478.2, ENSRNOT00000103896.2

    2. XM_008769638.4 → XP_008767860.2  ras GTPase-activating protein nGAP isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABU3

    3. XM_039090766.2 → XP_038946694.1  ras GTPase-activating protein nGAP isoform X11

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Conserved Domains (4) summary
      cd04013
      Location:132 → 271
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:262 → 592
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:582 → 1058
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:50 → 190
      PH-like; Pleckstrin homology-like domain

    4. XM_006250066.5 → XP_006250128.1  ras GTPase-activating protein nGAP isoform X6

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Conserved Domains (6) summary
      cd04013
      Location:159 → 298
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:289 → 619
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:282 → 620
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:609 → 1085
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:963 → 1102
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:34 → 217
      PH-like; Pleckstrin homology-like domain

    5. XM_063272346.1 → XP_063128416.1  ras GTPase-activating protein nGAP isoform X7

      UniProtKB/TrEMBL
      A0A8I6AI87
      Related
      ENSRNOP00000033372.5, ENSRNOT00000033324.7

    6. XM_039090765.2 → XP_038946693.1  ras GTPase-activating protein nGAP isoform X10

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Conserved Domains (4) summary
      cd04013
      Location:138 → 277
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:268 → 598
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:588 → 1064
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:56 → 196
      PH-like; Pleckstrin homology-like domain

    7. XM_063272345.1 → XP_063128415.1  ras GTPase-activating protein nGAP isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABU3

    8. XM_063272344.1 → XP_063128414.1  ras GTPase-activating protein nGAP isoform X3

      UniProtKB/TrEMBL
      A0A8I6ABU3

    9. XM_006250067.5 → XP_006250129.1  ras GTPase-activating protein nGAP isoform X12

      See identical proteins and their annotated locations for XP_006250129.1

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Conserved Domains (6) summary
      cd04013
      Location:131 → 270
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:261 → 591
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:254 → 592
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:581 → 1057
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:935 → 1074
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:6 → 189
      PH-like; Pleckstrin homology-like domain

    10. XM_039090764.2 → XP_038946692.1  ras GTPase-activating protein nGAP isoform X9

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Conserved Domains (4) summary
      cd04013
      Location:139 → 278
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:269 → 599
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:589 → 1065
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:57 → 197
      PH-like; Pleckstrin homology-like domain

    11. XM_063272347.1 → XP_063128417.1  ras GTPase-activating protein nGAP isoform X8

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Related
      ENSRNOP00000068634.3, ENSRNOT00000089062.3

    12. XM_006250065.4 → XP_006250127.1  ras GTPase-activating protein nGAP isoform X5

      UniProtKB/TrEMBL
      A0A8I6ABU3
      Conserved Domains (6) summary
      cd04013
      Location:162 → 301
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:292 → 622
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:285 → 623
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam12004
      Location:612 → 1088
      DUF3498; Domain of unknown function (DUF3498)
      cl02488
      Location:966 → 1105
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:37 → 220
      PH-like; Pleckstrin homology-like domain

    13. XM_063272348.1 → XP_063128418.1  ras GTPase-activating protein nGAP isoform X13

      UniProtKB/TrEMBL
      A0A8I6ABU3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107188.1: Suppressed sequence

      Description
      NM_001107188.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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