Ptgdrl1 prostaglandin D2 receptor-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgdrl1provided by RGD
Official Full Name: prostaglandin D2 receptor-like 1provided by RGD
Primary source: RGD:1565108
See related: EnsemblRapid:ENSRNOG00000031307 AllianceGenome:RGD:1565108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptgdr; Ptgdrl; RGD1565108
Summary: Predicted to enable prostaglandin D receptor activity. Predicted to be involved in inflammatory response and positive regulation of cytosolic calcium ion concentration. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 5.9), Testes (RPKM 2.8) and 7 other tissues See more
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Genomic context

Location:: 15p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (20552125..20561220, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (18072357..18081452, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (18089077..18095979, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the inhibitory effect of PGD(2) in the small intestine is mediated via activation of the DP1 receptor.
Title: CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Mit3 (e-PCR), detects polymorphism
- UniSTS:226670

BF391109 (e-PCR)
- UniSTS:249754

PMC58788P1 (e-PCR)
- UniSTS:273373

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostaglandin D receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostaglandin D2 receptor

Names: PGD receptor; PGD2 receptor; prostaglandin D receptor; prostanoid DP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.