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    SR1 signal responsive 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816762, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SR1
    Official Full Name
    signal responsive 1
    Primary source
    TAIR:AT2G22300
    Locus tag
    AT2G22300
    See related
    Araport:AT2G22300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3; CAMTA3; signal responsive 1; T26C19.4; T26C19_4
    Summary
    Encodes a putative CAM binding transcription factor. Loss of function mutations show enhanced resistance to fungal and bacterial pathogens suggesting that CAMTA functions to suppress defense responses.
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    Genomic context

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    See SR1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (9471219..9476646)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene RAB GTPase homolog H1D Neighboring gene ubiquitin-specific protease 4 Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA-Binding Activity of CAMTA3 Is Essential for Its Function: Identification of Critical Amino Acids for Its Transcriptional Activity. Prasad KVSK, et al. Cells, 2023 Aug 2. PMID 37566065, Free PMC Article
    2. Interplay between Ca(2+)/Calmodulin-Mediated Signaling and AtSR1/CAMTA3 during Increased Temperature Resulting in Compromised Immune Response in Plants. Yuan P, et al. Int J Mol Sci, 2022 Feb 16. PMID 35216293, Free PMC Article
    3. Calmodulin-binding transcription activator (CAMTA) 3 mediates biotic defense responses in Arabidopsis. Galon Y, et al. FEBS Lett, 2008 Mar 19. PMID 18298954
    4. A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana. Jacob F, et al. New Phytol, 2018 Mar. PMID 29226970, Free PMC Article
    5. Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3. Benn G, et al. Proc Natl Acad Sci U S A, 2016 Aug 2. PMID 27432993, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
      Title: CAMTA3 repressor destabilization triggers TIR domain protein TN2-mediated autoimmunity in the Arabidopsis exo70B1 mutant.
    2. DNA-Binding Activity of CAMTA3 Is Essential for Its Function: Identification of Critical Amino Acids for Its Transcriptional Activity.
      Title: DNA-Binding Activity of CAMTA3 Is Essential for Its Function: Identification of Critical Amino Acids for Its Transcriptional Activity.
    3. Interplay between Ca(2+)/Calmodulin-Mediated Signaling and AtSR1/CAMTA3 during Increased Temperature Resulting in Compromised Immune Response in Plants.
      Title: Interplay between Ca(2+)/Calmodulin-Mediated Signaling and AtSR1/CAMTA3 during Increased Temperature Resulting in Compromised Immune Response in Plants.
    4. CAMTA-mediated transcriptional regulation defines an early convergence point in NLR- and PRR-mediated signalling.
      Title: A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana.
    5. Genetics and pharmacological approaches confirmed the specificity of MEcPP in rapid stress response element (RSRE) induction via the transcription factor CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3 (CAMTA3), in a calcium-dependent manner.
      Title: Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3.
    6. These findings support a model in which DSC1 and DSC2 guard CAMTA3, and they suggest that other negative regulators of immunity may similarly represent guardees.
      Title: Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles.
    7. double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid
      Title: Distinct roles for mitogen-activated protein kinase signaling and CALMODULIN-BINDING TRANSCRIPTIONAL ACTIVATOR3 in regulating the peak time and amplitude of the plant general stress response.
    8. CAMTA1, CAMTA2 and CAMTA3 function together to inhibit salicylic acid biosynthesis at warm temperature (22 degrees C).CAMTA1, CAMTA2 and CAMTA3 function together to positively regulate CBF1, CBF2 and CBF3 and freezing tolerance.
      Title: Roles of CAMTA transcription factors and salicylic acid in configuring the low-temperature transcriptome and freezing tolerance of Arabidopsis.
    9. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
      Title: SR1, a calmodulin-binding transcription factor, modulates plant defense and ethylene-induced senescence by directly regulating NDR1 and EIN3.
    10. Ca(2+)/Calmodulin-mediated signaling regulates plant response to herbivore attack/wounding by modulating the salicylic acid-jasmonic acid crosstalk through AtSR1.
      Title: Coupling calcium/calmodulin-mediated signaling and herbivore-induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001124889.2
    NM_001335795.1
    NM_179692.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cold IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular ATP signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    signal responsive 1
    NP_001118361.1
    • signal responsive 1 (SR1); FUNCTIONS IN: calmodulin binding, transcription regulator activity; INVOLVED IN: response to biotic stimulus; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Ankyrin repeat-containing domain (InterPro:IPR020683), CG-1 (InterPro:IPR005559), Ankyrin repeat (InterPro:IPR002110), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: Calmodulin-binding transcription activator protein with CG-1 and Ankyrin domains (TAIR:AT5G64220.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_850023.1
    • signal responsive 1 (SR1); FUNCTIONS IN: calmodulin binding, transcription regulator activity; INVOLVED IN: response to biotic stimulus; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Ankyrin repeat-containing domain (InterPro:IPR020683), CG-1 (InterPro:IPR005559), Ankyrin repeat (InterPro:IPR002110), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: Calmodulin-binding transcription activator protein with CG-1 and Ankyrin domains (TAIR:AT5G64220.2); Has 5346 Blast hits to 4463 proteins in 355 species: Archae - 34; Bacteria - 421; Metazoa - 3055; Fungi - 454; Plants - 566; Viruses - 42; Other Eukaryotes - 774 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9471219..9476646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001124889.2 → NP_001118361.1  signal responsive 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WW70, Q8GSA7, Q9FPR9, Q9SID7
      UniProtKB/TrEMBL
      A0A178VUE5
      Conserved Domains (4) summary
      PHA03095
      Location:620 → 746
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:661 → 692
      ANK; ANK repeat [structural motif]
      pfam03859
      Location:23 → 135
      CG-1; CG-1 domain
      cd21759
      Location:857 → 988
      CBD_MYO6-like; calmodulin binding domain found in unconventional myosin-VI and similar proteins

    2. NM_001335795.1 → NP_001325089.1  signal responsive 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VUE5, A0A1P8B262

    3. NM_179692.3 → NP_850023.1  signal responsive 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WW70, Q8GSA7, Q9FPR9, Q9SID7
      UniProtKB/TrEMBL
      A0A178VUE5
      Conserved Domains (4) summary
      PHA03095
      Location:620 → 746
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:661 → 692
      ANK; ANK repeat [structural motif]
      pfam03859
      Location:23 → 135
      CG-1; CG-1 domain
      cd21759
      Location:857 → 988
      CBD_MYO6-like; calmodulin binding domain found in unconventional myosin-VI and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GSA7.1

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