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    Cdkl2 cyclin dependent kinase like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdkl2provided by RGD
    Official Full Name
    cyclin dependent kinase like 2provided by RGD
    Primary source
    RGD:1309625
    See related
    EnsemblRapid:ENSRNOG00000002506 AllianceGenome:RGD:1309625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 93.9), Testes (RPKM 42.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkl2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16312154..16347524)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (16027381..16063257)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17530170..17565950)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 1 Neighboring gene uncharacterized LOC120096578 Neighboring gene small Cajal body-specific RNA 23 like 2 Neighboring gene Sec61 translocon subunit gamma, pseudogene 2 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene THAP domain containing 6 Neighboring gene ring finger and CHY zinc finger domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 2
    Names
    cyclin-dependent kinase-like 2 (CDC2-related kinase)
    NP_001012035.2
    XP_063129130.1
    XP_063129131.1
    XP_063129132.1
    XP_063129133.1
    XP_063129134.1
    XP_063129135.1
    XP_063129136.1
    XP_063129137.1
    XP_063129138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012035.2 → NP_001012035.2  cyclin-dependent kinase-like 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
      Related
      ENSRNOP00000049130.4, ENSRNOT00000050038.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      16312154..16347524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273060.1 → XP_063129130.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
      Related
      ENSRNOP00000073081.3, ENSRNOT00000079304.3

    2. XM_063273062.1 → XP_063129132.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    3. XM_063273066.1 → XP_063129136.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    4. XM_063273067.1 → XP_063129137.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    5. XM_063273061.1 → XP_063129131.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    6. XM_063273065.1 → XP_063129135.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    7. XM_063273063.1 → XP_063129133.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    8. XM_063273068.1 → XP_063129138.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5

    9. XM_063273064.1 → XP_063129134.1  cyclin-dependent kinase-like 2 isoform X1

      UniProtKB/TrEMBL
      A6KKB1, F7F9E5
      Related
      ENSRNOP00000045371.4, ENSRNOT00000046771.6

    RNA

    1. XR_005492936.2 RNA Sequence

    2. XR_005492939.2 RNA Sequence

    3. XR_005492943.2 RNA Sequence

    4. XR_005492940.2 RNA Sequence

    5. XR_005492944.2 RNA Sequence

    6. XR_005492937.2 RNA Sequence

    7. XR_005492941.2 RNA Sequence

    8. XR_005492945.2 RNA Sequence

    9. XR_005492938.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIT0.1 GenPept UniProtKB/Swiss-Prot:Q5XIT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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