Ppbp pro-platelet basic protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppbpprovided by RGD
Official Full Name: pro-platelet basic proteinprovided by RGD
Primary source: RGD:70548
See related: EnsemblRapid:ENSRNOG00000002829 AllianceGenome:RGD:70548
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cxcl7; Nap-2
Summary: Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in positive regulation of granulocyte chemotaxis. Predicted to be located in platelet alpha granule. Predicted to be active in extracellular space. Biomarker of acute myocardial infarction and hypospadias. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to human PPBP (pro-platelet basic protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 335.0) See more
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Genomic context

Location:: 14p22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (17586495..17587299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (17302326..17303130, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (18852433..18853237, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular cloning and characterization; may have the function to recruit PMNs to fight against pulmonary infection
Title: Molecular cloning and characterization of a novel rat CXC chemokine, rPBP, the homologue of human and mouse PBP.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemokine activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of granulocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet basic protein

Names: chemokine (C-X-C motif) ligand 7; neutrophil activating peptide-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153721.1 → NP_714943.1 platelet basic protein precursor

See identical proteins and their annotated locations for NP_714943.1

Status: PROVISIONAL

Source sequence(s)

AF349115

UniProtKB/TrEMBL

A6KKE5, F7EY20, Q99ME0

Related

ENSRNOP00000003794.1, ENSRNOT00000003794.5

Conserved Domains (1) summary

cd00273
Location:47 → 109

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...