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    RAD51D DNA repair RAD51-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837289, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAD51D
    Official Full Name
    DNA repair RAD51-like protein
    Primary source
    TAIR:AT1G07745
    Locus tag
    AT1G07745
    See related
    Araport:AT1G07745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAD51D; F24B9.14; F24B9_14; homolog of RAD51 D; SSN1; SUPPRESOR OF SNI1
    Summary
    Is a suppressor of SNI1. Encodes a member of the RecA/RAD51 family of DNA recombination and repair proteins. Both RAD51 and SNI1 have a dual role in pathogen-related gene transcription and somatic homologous recombination.
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    Genomic context

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    See RAD51D in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (2400589..2402942, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene exocyst subunit exo70 family protein H6 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Disease resistance-responsive (dirigent-like protein) family protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene RmlC-like cupins superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The recombination mediator RAD51D promotes geminiviral infection. Richter KS, et al. Virology, 2016 Jun. PMID 27018825
    2. Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response. Durrant WE, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360504, Free PMC Article
    3. Roles of XRCC2, RAD51B and RAD51D in RAD51-independent SSA recombination. Serra H, et al. PLoS Genet, 2013 Nov. PMID 24278037, Free PMC Article
    4. DNA repair proteins are directly involved in regulation of gene expression during plant immune response. Song J, et al. Cell Host Microbe, 2011 Feb 17. PMID 21320694
    5. Arabidopsis lamin-like proteins CRWN1 and CRWN2 interact with SUPPRESSOR OF NPR1-1 INDUCIBLE 1 and RAD51D to prevent DNA damage. Yin C, et al. Plant Cell, 2023 Sep 1. PMID 37335899, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAD51D promotes viral replication at early stages of infection
      Title: The recombination mediator RAD51D promotes geminiviral infection.
    2. Notwithstanding their clearly established importance for RAD51-dependent homologous recombination, XRCC2, RAD51B and RAD51D thus also participate in Single-Strand Annealing recombination.
      Title: Roles of XRCC2, RAD51B and RAD51D in RAD51-independent SSA recombination.
    3. SSN2 and RAD51D are directly involved in regulation of gene expression during plant immune response.
      Title: DNA repair proteins are directly involved in regulation of gene expression during plant immune response.
    4. RAD51D and SNI1 have dual roles in pathogenesis-related gene transcription and DNA recombination
      Title: Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084010.2
    NM_001331725.1
    NM_001331726.1
    NM_001331727.1
    NM_100649.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic cell DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair RAD51-like protein
    NP_001077479.1
    • homolog of RAD51 D (RAD51D); FUNCTIONS IN: nucleoside-triphosphatase activity, DNA-dependent ATPase activity, DNA binding, nucleotide binding, ATP binding; INVOLVED IN: DNA repair, somatic cell DNA recombination, regulation of response to biotic stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: sperm cell, male gametophyte, flower; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT2G28560.1); Has 4124 Blast hits to 4124 proteins in 1258 species: Archae - 446; Bacteria - 1629; Metazoa - 719; Fungi - 404; Plants - 385; Viruses - 2; Other Eukaryotes - 539 (source: NCBI BLink).
    NP_172254.2
    • homolog of RAD51 D (RAD51D); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: DNA repair, somatic cell DNA recombination, regulation of response to biotic stimulus; EXPRESSED IN: sperm cell, male gametophyte, flower; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT2G28560.1); Has 4147 Blast hits to 4147 proteins in 1269 species: Archae - 448; Bacteria - 1641; Metazoa - 721; Fungi - 410; Plants - 391; Viruses - 2; Other Eukaryotes - 534 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2400589..2402942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084010.2 → NP_001077479.1  DNA repair RAD51-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MSF8
      Conserved Domains (2) summary
      PRK09361
      Location:71 → 293
      radB; DNA repair and recombination protein RadB; Provisional
      cl21455
      Location:71 → 296
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001331725.1 → NP_001322150.1  DNA repair RAD51-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AT83

    3. NM_001331726.1 → NP_001322151.1  DNA repair RAD51-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3QS63, A3QS64

    4. NM_100649.3 → NP_172254.2  DNA repair RAD51-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172254.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5K4Q1, Q9LQQ2
      UniProtKB/TrEMBL
      A0A654E7Y7, A3QS62
      Conserved Domains (2) summary
      cd19489
      Location:101 → 301
      Rad51D; RAD51D recombinase
      cl38936
      Location:58 → 131
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001331727.1 → NP_001322152.1  DNA repair RAD51-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3QS63, A3QS64
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQQ2.2

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