U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    traf2a Tnf receptor-associated factor 2a [ Danio rerio (zebrafish) ]

    Gene ID: 564295, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    traf2aprovided by ZNC
    Official Full Name
    Tnf receptor-associated factor 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071120-2
    See related
    Ensembl:ENSDARG00000030173 AllianceGenome:ZFIN:ZDB-GENE-071120-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable signaling adaptor activity; tumor necrosis factor receptor binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See traf2a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (28752520..28768113, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (28152363..28168010, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tenascin Cb Neighboring gene uncharacterized LOC137495594 Neighboring gene uncharacterized LOC137495517 Neighboring gene si:ch211-186e20.7 Neighboring gene TRAF-type zinc finger domain containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. Smith CJ, et al. PLoS Genet, 2017 Apr. PMID 28379965, Free PMC Article
    2. Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Xu ZY, et al. Vet Immunol Immunopathol, 2008 Jan 15. PMID 17868904
    3. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
    4. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    TNF receptor-associated factor 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      28752520..28768113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476484.2 → XP_021332159.1  TNF receptor-associated factor 2

      UniProtKB/TrEMBL
      A0A8M9PY87, E7EXH5
      Conserved Domains (5) summary
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cl02446
      Location:411 → 571
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:341 → 403
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cl17238
      Location:32 → 73
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl28410
      Location:34 → 157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    2. XM_021476485.2 → XP_021332160.1  TNF receptor-associated factor 2

      UniProtKB/TrEMBL
      A0A8M9PY87, E7EXH5
      Related
      ENSDARP00000043465.6, ENSDART00000043466.7
      Conserved Domains (5) summary
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cl02446
      Location:411 → 571
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:341 → 403
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cl17238
      Location:32 → 73
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl28410
      Location:34 → 157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394579.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      220631..235904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471606.2 → XP_021327281.1  TNF receptor-associated factor 2

      UniProtKB/TrEMBL
      A0A8M9PY87, E7EXH5
      Conserved Domains (5) summary
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cl02446
      Location:411 → 571
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:341 → 403
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cl17238
      Location:32 → 73
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl28410
      Location:34 → 157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395237.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      25425..39842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171946.5 → XP_005172003.1  TNF receptor-associated factor 2

      UniProtKB/TrEMBL
      A0A8M9PY87, E7EXH5
      Conserved Domains (5) summary
      pfam02176
      Location:178 → 235
      zf-TRAF; TRAF-type zinc finger
      cl02446
      Location:411 → 571
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      pfam16673
      Location:341 → 403
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cl17238
      Location:32 → 73
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
      cl28410
      Location:34 → 157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    2. XM_068219184.1 → XP_068075285.1  TNF receptor-associated factor 2

      UniProtKB/TrEMBL
      A0A8M9PY87, E7EXH5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials