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    selenow2b selenoprotein W, 2b [ Danio rerio (zebrafish) ]

    Gene ID: 378438, updated on 9-Dec-2024

    Summary

    Official Symbol
    selenow2bprovided by ZNC
    Official Full Name
    selenoprotein W, 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030428-2
    See related
    Ensembl:ENSDARG00000089936 AllianceGenome:ZFIN:ZDB-GENE-030428-2
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb696; sepw2b; zgc:123142; zgc:152839; si:dz180g5.2
    Summary
    This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Unlike in mammals, where this protein is highly expressed in skeletal muscle, heart and brain; it is expressed in sensory organs in zebrafish. Paralogs of this gene, sepw1 and sepw2a, are found on chromosomes 5 and 3, respectively. [provided by RefSeq, Jul 2017]
    Orthologs
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    Genomic context

    See selenow2b in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (20103745..20106220, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (19954005..19956471, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene upstream binding transcription factor Neighboring gene solute carrier family 4 member 1a (Diego blood group) Neighboring gene selenoprotein W, 2a Neighboring gene nerve growth factor receptor a (TNFR superfamily, member 16)

    Genomic regions, transcripts, and products

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194418.3NP_919399.3  selenoprotein W, 2b

      Status: REVIEWED

      Source sequence(s)
      BC124148, CK687346, DV591466, EH468996
      UniProtKB/TrEMBL
      A0A8M1PB21
      Related
      ENSDARP00000118513.1, ENSDART00000145285.3
      Conserved Domains (1) summary
      TIGR02174
      Location:575
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      20103745..20106220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394528.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      11570..14045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)