tmsb4x thymosin beta 4 X-linked [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmsb4xprovided by ZNC
Official Full Name: thymosin beta 4 X-linkedprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8304
See related: Ensembl:ENSDARG00000077777 AllianceGenome:ZFIN:ZDB-GENE-030131-8304
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Tbeta11; fb08c07; fj40h03; wu:fb08c07; wu:fj40h03; zgc:195154
Summary: Predicted to enable actin monomer binding activity. Acts upstream of or within heart development and pronephros development. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in heart; heart rudiment; heart tube; and lateral plate mesoderm. Orthologous to several human genes including TMSB4X (thymosin beta 4 X-linked). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (54178475..54180062)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (54612562..54614149)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role in cardiac valve formation by increasing endothelial-mesenchymal transformation
Title: Thymosin beta4 regulates cardiac valve formation via endothelial-mesenchymal transformation in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

fa92d06.x1 (e-PCR)
- UniSTS:202566

fj40h03.x1 (e-PCR)
- UniSTS:199298

fb07e06.x1 (e-PCR)
- UniSTS:189942

fb07e06.x1 (e-PCR)
- UniSTS:189943

fb08c07.x1 (e-PCR)
- UniSTS:202751

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within atrioventricular canal development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymosin beta-4

Names: beta thymosin-like; thymosin beta-11; thymosin, beta 4 x; zTB4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.