vmp1 vacuole membrane protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vmp1provided by ZNC
Official Full Name: vacuole membrane protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8733
See related: Ensembl:ENSDARG00000012450 AllianceGenome:ZFIN:ZDB-GENE-030131-8733
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tmem49; zgc:77153; wu:fb05d08; wu:fb92g08
Summary: Predicted to enable phospholipid scramblase activity. Involved in lipoprotein transport. Acts upstream of or within autophagy. Predicted to be located in bounding membrane of organelle; endoplasmic reticulum membrane; and plasma membrane. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including EVL; digestive system; intestinal bulb primordium; nervous system; and optic vesicle. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (17343349..17373353)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (17407267..17437331)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables phospholipid scramblase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vacuole membrane protein 1

Names: transmembrane protein 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207060.1 → NP_996943.1 vacuole membrane protein 1

See identical proteins and their annotated locations for NP_996943.1

Status: PROVISIONAL

Source sequence(s)

BC066412

UniProtKB/Swiss-Prot

Q6NYY9

Related

ENSDARP00000098034.3, ENSDART00000111753.3

Conserved Domains (1) summary

cl00429
Location:247 → 298

SNARE_assoc; SNARE associated Golgi protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

17343349..17373353

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157413.5 → XP_005157470.1 vacuole membrane protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B471, F1Q6C7, F1QFE0

Related

ENSDARP00000004153.8, ENSDART00000018461.10

Conserved Domains (1) summary

cl00429
Location:247 → 298

SNARE_assoc; SNARE associated Golgi protein