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    mapre1b microtubule-associated protein, RP/EB family, member 1b [ Danio rerio (zebrafish) ]

    Gene ID: 334728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mapre1bprovided by ZNC
    Official Full Name
    microtubule-associated protein, RP/EB family, member 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2256
    See related
    Ensembl:ENSDARG00000002659 AllianceGenome:ZFIN:ZDB-GENE-040426-2256
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mapre1; zgc:85755; wu:fa01e12; wu:fc23e11
    Summary
    Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in plasma membrane. Predicted to be active in microtubule cytoskeleton. Is expressed in oocyte stage IV and ovarian follicle stage IV. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mapre1b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (9794679..9807560, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (9859709..9872618, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ADRM1 26S proteasome ubiquitin receptor Neighboring gene laminin, alpha 5 Neighboring gene protein kinase C binding protein 1, like Neighboring gene si:ch211-220i18.4 Neighboring gene solute carrier family 16 member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Staufen1, Kinesin1 and microtubule function in cyclin B1 mRNA transport to the animal polar cytoplasm of zebrafish oocytes. Takahashi K, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30103945
    2. The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Chiang DY, et al. Circ Res, 2024 Jan 5. PMID 38095085
    3. Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs. Marchal GA, et al. Circ Res, 2021 Jul 23. PMID 34092082, Free PMC Article
    4. Transcriptomic Profiling Revealed Signaling Pathways Associated with the Spawning of Female Zebrafish under Cold Stress. Ge G, et al. Int J Mol Sci, 2022 Jul 6. PMID 35886843, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein RP/EB family member 1b
    Names
    microtubule-associated protein, RP/EB family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213640.1 → NP_998805.1  microtubule-associated protein RP/EB family member 1b

      See identical proteins and their annotated locations for NP_998805.1

      Status: PROVISIONAL

      Source sequence(s)
      BC068377
      UniProtKB/TrEMBL
      A0A8M1PJQ9, Q6NUY9
      Related
      ENSDARP00000010960.7, ENSDART00000004474.9
      Conserved Domains (2) summary
      pfam00307
      Location:16 → 100
      CH; Calponin homology (CH) domain
      pfam03271
      Location:203 → 240
      EB1; EB1-like C-terminal motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      9794679..9807560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161949.4 → XP_005162006.2  microtubule-associated protein RP/EB family member 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B926
      Related
      ENSDARP00000120869.1, ENSDART00000136740.3
      Conserved Domains (3) summary
      COG5217
      Location:16 → 269
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
      pfam00307
      Location:16 → 100
      CH; Calponin homology (CH) domain
      pfam03271
      Location:219 → 256
      EB1; EB1-like C-terminal motif
    Nucleotide Protein Strain
    Heading Accession and Version

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