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    si:dkey-243i1.1 si:dkey-243i1.1 [ Danio rerio (zebrafish) ]

    Gene ID: 563653, updated on 4-Jan-2025

    Summary

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    Official Symbol
    si:dkey-243i1.1provided by ZNC
    Official Full Name
    si:dkey-243i1.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6399
    See related
    Ensembl:ENSDARG00000034227 AllianceGenome:ZFIN:ZDB-GENE-030131-6399
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi75d06
    Summary
    Acts upstream of or within cranial skeletal system development. Predicted to be active in centriolar satellite. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Joubert syndrome; asphyxiating thoracic dystrophy; and orofaciodigital syndrome. Orthologous to human KIAA0753 (KIAA0753). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See si:dkey-243i1.1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (26848909..26886954, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (26916029..26954085, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 47 member 5 Neighboring gene PITPNM family member 3 Neighboring gene coiled-coil domain containing 9 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1Da

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Novel KIAA0753 mutations extend the phenotype of skeletal ciliopathies. Hammarsjö A, et al. Sci Rep, 2017 Nov 14. PMID 29138412, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein KIAA0753; protein moonraker

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      26848909..26886954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466437.2 → XP_021322112.1  protein moonraker isoform X3

      UniProtKB/TrEMBL
      A0A8M9NYN9
      Conserved Domains (1) summary
      pfam15718
      Location:37 → 846
      MNR; Protein moonraker

    2. XM_005157662.5 → XP_005157719.1  protein moonraker isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4L0
      Conserved Domains (1) summary
      pfam15718
      Location:37 → 865
      DUF4673; Domain of unknown function (DUF4673)

    3. XM_687010.10 → XP_692102.5  protein moonraker isoform X1

      UniProtKB/TrEMBL
      A0A8N7TB65, X1WC30
      Related
      ENSDARP00000127773.1, ENSDART00000156292.2
      Conserved Domains (1) summary
      pfam15718
      Location:37 → 866
      DUF4673; Domain of unknown function (DUF4673)
    Nucleotide Protein Strain
    Heading Accession and Version

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