nrf1 nuclear respiratory factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrf1provided by ZNC
Official Full Name: nuclear respiratory factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-001221-1
See related: Ensembl:ENSDARG00000000018 AllianceGenome:ZFIN:ZDB-GENE-001221-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ube2h; SC:BZ3C13.1; SC:bZ3C13.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in neural retina development. Acts upstream of or within several processes, including cellular response to cold; photoreceptor cell maintenance; and response to activity. Predicted to be active in nucleus. Is expressed in heart; nervous system; optic cup; and visceral fat. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (15081385..15103696, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (15082630..15104941, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Nrf1a or Nrf1b perturbed glutathione redox state in zebrafish embryo. Nrf1 alone is not essential for the response and recovery of glutathione to oxidative insults.
Title: The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fe12h02.y1 (e-PCR)
- UniSTS:196124

fj85c05.y1 (e-PCR)
- UniSTS:200110

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info
involved_in neural retina development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina homeostasis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: nuclear respiratory factor 1

Names: not really finished protein; nrf; nrf-1; nrl

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328540.1 → NP_001315469.1 nuclear respiratory factor 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL590150

UniProtKB/Swiss-Prot

O93570, Q7ZTS6, Q90X44

Related

ENSDARP00000149440.1, ENSDART00000181044.1

Conserved Domains (2) summary

pfam10492
Location:461 → 514

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:87 → 284

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_131680.2 → NP_571755.2 nuclear respiratory factor 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL590150

UniProtKB/Swiss-Prot

Q90X44

Related

ENSDARP00000116798.1, ENSDART00000138183.2