lcp1 lymphocyte cytosolic protein 1 (L-plastin) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lcp1provided by ZNC
Official Full Name: lymphocyte cytosolic protein 1 (L-plastin)provided by ZNC
Primary source: ZFIN:ZDB-GENE-991213-5
See related: Ensembl:ENSDARG00000023188 AllianceGenome:ZFIN:ZDB-GENE-991213-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb245; fj24b12; wu:fj24b12
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Located in cytoplasm. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (56251000..56272465, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (56663225..56670983, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

lcp1 (e-PCR), detects polymorphism
- UniSTS:205580

z1566 (e-PCR), detects polymorphism
- UniSTS:205132

fl22f07.x1 (e-PCR)
- UniSTS:202066

fj91e04.y1 (e-PCR)
- UniSTS:200306

G45086 (e-PCR)
- UniSTS:105888

fj24b12.x1 (e-PCR)
- UniSTS:198846

G46672 (e-PCR)
- UniSTS:107471

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plastin-2

Names: L-plastin; leucocyte-specific plastin 1; lymphocyte cytosolic plastin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131320.3 → NP_571395.2 plastin-2

See identical proteins and their annotated locations for NP_571395.2

Status: VALIDATED

Source sequence(s)

CU914623, FO905030

UniProtKB/Swiss-Prot

Q6P698, Q9W746

UniProtKB/TrEMBL

A0A140LGK1, A0A140LGV0, A0A8N7UZJ0

Related

ENSDARP00000142380.2, ENSDART00000039235.8

Conserved Domains (4) summary

smart00033
Location:396 → 499

CH; Calponin homology domain

cd00014
Location:119 → 234

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:13 → 79

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:14 → 78

EF-hand_7; EF-hand domain pair