eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif2b5provided by ZNC
Official Full Name: eukaryotic translation initiation factor 2B, subunit 5 epsilonprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5364
See related: Ensembl:ENSDARG00000074995 AllianceGenome:ZFIN:ZDB-GENE-030131-5364
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fd14g07; wu:fd14g07
Summary: Predicted to enable guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in brain; eye; myotome; optic vesicle; and pharyngeal arch. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 5. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (2904080..2917148)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (3062181..3075249)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response.
Title: Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response.

Submit: New GeneRIF Correction

General gene information

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Markers

fc80a03.x1 (e-PCR)
- UniSTS:194562

fd14g07.x1 (e-PCR)
- UniSTS:204183

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: translation initiation factor eIF2B subunit epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113597.1 → NP_001107069.1 translation initiation factor eIF2B subunit epsilon

See identical proteins and their annotated locations for NP_001107069.1

Status: PROVISIONAL

Source sequence(s)

BC154595

UniProtKB/TrEMBL

A8WG65

Related

ENSDARP00000099342.3, ENSDART00000110416.5

Conserved Domains (5) summary

cd05787
Location:343 → 421

LbH_eIF2B_epsilon; eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...

cd04197
Location:25 → 239

eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2

cd11558
Location:531 → 693

W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon

COG1208
Location:24 → 432

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:302 → 370

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...