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    osgep O-sialoglycoprotein endopeptidase [ Danio rerio (zebrafish) ]

    Gene ID: 550447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osgepprovided by ZNC
    Official Full Name
    O-sialoglycoprotein endopeptidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7880
    See related
    Ensembl:ENSDARG00000045846 AllianceGenome:ZFIN:ZDB-GENE-030131-7880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj38e02; wu:fj38e02; zgc:112527; si:ch211-214j24.11
    Summary
    Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to act upstream of or within tRNA processing. Predicted to be located in nucleus. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 3. Orthologous to human OSGEP (O-sialoglycoprotein endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See osgep in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5327629..5333766, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5319059..5325196, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:ch211-214j24.15 Neighboring gene si:ch211-214j24.10 Neighboring gene APEX nuclease (multifunctional DNA repair enzyme) 1 Neighboring gene zgc:113263 Neighboring gene si:dkey-14d8.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model. Jobst-Schwan T, et al. PLoS One, 2018. PMID 29346415, Free PMC Article
    2. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Braun DA, et al. Nat Genet, 2017 Oct. PMID 28805828, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EKC/KEOPS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of EKC/KEOPS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N6-adenosine threonylcarbamoyltransferase
    Names
    probable tRNA N6-adenosine threonylcarbamoyltransferase
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep
    tRNA threonylcarbamoyladenosine biosynthesis protein osgep
    NP_001017751.2
    XP_021330688.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017751.2 → NP_001017751.2  tRNA N6-adenosine threonylcarbamoyltransferase

      See identical proteins and their annotated locations for NP_001017751.2

      Status: VALIDATED

      Source sequence(s)
      BC093366, EH455691, EH528749
      UniProtKB/Swiss-Prot
      Q561S3, Q5RHZ6
      UniProtKB/TrEMBL
      A0A8M9PUE5
      Related
      ENSDARP00000067374.4, ENSDART00000067375.5
      Conserved Domains (1) summary
      PTZ00340
      Location:2 → 335
      PTZ00340; O-sialoglycoprotein endopeptidase-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      5327629..5333766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475013.2 → XP_021330688.1  tRNA N6-adenosine threonylcarbamoyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q561S3, Q5RHZ6
      UniProtKB/TrEMBL
      A0A8M9PUE5
      Related
      ENSDARP00000118646.2, ENSDART00000144225.4
      Conserved Domains (1) summary
      PTZ00340
      Location:2 → 335
      PTZ00340; O-sialoglycoprotein endopeptidase-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RHZ6.1 GenPept UniProtKB/Swiss-Prot:Q5RHZ6

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