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    klhl13 kelch-like family member 13 [ Danio rerio (zebrafish) ]

    Gene ID: 323951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klhl13provided by ZNC
    Official Full Name
    kelch-like family member 13provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2671
    See related
    Ensembl:ENSDARG00000086463 Ensembl:ENSDARG00000103786 AllianceGenome:ZFIN:ZDB-GENE-030131-2671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc15b07; zgc:163008
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in olfactory bulb and telencephalon. Orthologous to several human genes including KLHL13 (kelch like family member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See klhl13 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37343614..37440460)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36743448..36840307)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:163098 Neighboring gene WD repeat domain 44 Neighboring gene uncharacterized LOC137495610 Neighboring gene si:ch1073-224n8.1 Neighboring gene leucine-rich repeat neuronal protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099229.1 → NP_001092699.2  kelch-like protein 13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BC141798
      UniProtKB/TrEMBL
      A0A8M1NDF2, A5D8S9
      Related
      ENSDARP00000112236.2, ENSDART00000128122.3
      Conserved Domains (6) summary
      smart00612
      Location:429 → 474
      Kelch; Kelch domain
      PHA03098
      Location:78 → 621
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365 → 413
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:68 → 174
      BTB; BTB/POZ domain
      pfam01344
      Location:364 → 414
      Kelch_1; Kelch motif
      pfam07707
      Location:182 → 283
      BACK; BTB And C-terminal Kelch

    2. NM_001244754.1 → NP_001231683.1  kelch-like protein 13 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      EH115172, FP017278
      UniProtKB/TrEMBL
      A0A8M1P401, A5D8S9
      Related
      ENSDARP00000131113.1, ENSDART00000164459.2
      Conserved Domains (6) summary
      smart00612
      Location:457 → 502
      Kelch; Kelch domain
      PHA03098
      Location:106 → 649
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:393 → 441
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:96 → 202
      BTB; BTB/POZ domain
      pfam01344
      Location:392 → 442
      Kelch_1; Kelch motif
      pfam07707
      Location:210 → 311
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      37343614..37440460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356040.3 → XP_017211529.1  kelch-like protein 13 isoform X2

      UniProtKB/TrEMBL
      A0A0R4ICR0, A0A8M6YY58, A5D8S9

    2. XM_068221099.1 → XP_068077200.1  kelch-like protein 13 isoform X5

      UniProtKB/TrEMBL
      A0A8M2BCL7, A5D8S9

    3. XM_005165275.5 → XP_005165332.1  kelch-like protein 13 isoform X5

      UniProtKB/TrEMBL
      A0A8M2BCL7, A5D8S9
      Conserved Domains (6) summary
      smart00612
      Location:433 → 478
      Kelch; Kelch domain
      PHA03098
      Location:82 → 625
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:369 → 417
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:72 → 178
      BTB; BTB/POZ domain
      pfam01344
      Location:368 → 418
      Kelch_1; Kelch motif
      pfam07707
      Location:186 → 287
      BACK; BTB And C-terminal Kelch

    4. XM_005165273.5 → XP_005165330.1  kelch-like protein 13 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BCI0, A5D8S9
      Conserved Domains (6) summary
      smart00612
      Location:453 → 498
      Kelch; Kelch domain
      PHA03098
      Location:102 → 645
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:389 → 437
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:92 → 198
      BTB; BTB/POZ domain
      pfam01344
      Location:388 → 438
      Kelch_1; Kelch motif
      pfam07707
      Location:206 → 307
      BACK; BTB And C-terminal Kelch

    5. XM_005165276.5 → XP_005165333.1  kelch-like protein 13 isoform X6

      UniProtKB/TrEMBL
      A0A8M2BCJ7, A5D8S9, F1REQ9
      Conserved Domains (6) summary
      smart00612
      Location:429 → 474
      Kelch; Kelch domain
      PHA03098
      Location:78 → 621
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365 → 413
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:68 → 174
      BTB; BTB/POZ domain
      pfam01344
      Location:364 → 414
      Kelch_1; Kelch motif
      pfam07707
      Location:182 → 283
      BACK; BTB And C-terminal Kelch

    6. XM_005165272.5 → XP_005165329.1  kelch-like protein 13 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q9E7, A0A8M2BCQ1, A5D8S9
      Conserved Domains (6) summary
      smart00612
      Location:468 → 513
      Kelch; Kelch domain
      PHA03098
      Location:117 → 660
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:404 → 452
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:107 → 213
      BTB; BTB/POZ domain
      pfam01344
      Location:403 → 453
      Kelch_1; Kelch motif
      pfam07707
      Location:221 → 322
      BACK; BTB And C-terminal Kelch

    7. XM_005165274.5 → XP_005165331.1  kelch-like protein 13 isoform X4

      UniProtKB/TrEMBL
      A0A0R4IP02, A0A8M2BCJ0, A5D8S9
      Related
      ENSDARP00000137085.2, ENSDART00000171826.2
      Conserved Domains (6) summary
      smart00612
      Location:444 → 489
      Kelch; Kelch domain
      PHA03098
      Location:93 → 636
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:380 → 428
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:83 → 189
      BTB; BTB/POZ domain
      pfam01344
      Location:379 → 429
      Kelch_1; Kelch motif
      pfam07707
      Location:197 → 298
      BACK; BTB And C-terminal Kelch

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395241.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      219095..231501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395375.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      234275..330436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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