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    pcxb pyruvate carboxylase b [ Danio rerio (zebrafish) ]

    Gene ID: 58068, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcxbprovided by ZNC
    Official Full Name
    pyruvate carboxylase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000831-1
    See related
    Ensembl:ENSDARG00000051939 AllianceGenome:ZFIN:ZDB-GENE-000831-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pc; pyc; PYCb; wu:fb82g08; wu:fj85g01
    Summary
    Predicted to enable pyruvate carboxylase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pcxb in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (60457138..60831082, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (60151901..60525845, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Bb Neighboring gene BRMS1 transcriptional repressor and anoikis regulator Neighboring gene uncharacterized LOC110439982 Neighboring gene leucine-rich repeat and fibronectin type-III domain-containing protein 4 Neighboring gene uncharacterized LOC103911428 Neighboring gene uncharacterized LOC110439981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13. Yoder JA, et al. Gene, 2000 Dec 31. PMID 11167010
    2. Profiling hepatic microRNAs in zebrafish: fluoxetine exposure mimics a fasting response that targets AMP-activated protein kinase (AMPK). Craig PM, et al. PLoS One, 2014. PMID 24751937, Free PMC Article
    3. In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Pradhan A, et al. Chem Biol Interact, 2015 May 25. PMID 25818047
    4. Conservation of the Nrf2-Mediated Gene Regulation of Proteasome Subunits and Glucose Metabolism in Zebrafish. Nguyen VT, et al. Oxid Med Cell Longev, 2016. PMID 28116036, Free PMC Article
    5. Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Gonzalez P, et al. Environ Sci Technol, 2005 Jun 1. PMID 15984772

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate carboxylase, mitochondrial
    NP_571625.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131550.2 → NP_571625.2  pyruvate carboxylase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BX284674, BX294163, BX470085, CT030203, EB794119, EH595604, EH613146
      UniProtKB/TrEMBL
      A0A8N7UZL1, F1QYZ6
      Related
      ENSDARP00000068144.2, ENSDART00000073654.4
      Conserved Domains (7) summary
      cd06850
      Location:1113 → 1179
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd07937
      Location:567 → 850
      DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
      smart00878
      Location:377 → 484
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      PRK12999
      Location:38 → 1179
      PRK12999; pyruvate carboxylase; Reviewed
      pfam00289
      Location:39 → 147
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02436
      Location:863 → 1062
      PYC_OADA; Conserved carboxylase domain
      cl17255
      Location:153 → 360
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      60457138..60831082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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