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    pou2f1a POU class 2 homeobox 1a [ Danio rerio (zebrafish) ]

    Gene ID: 30715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pou2f1aprovided by ZNC
    Official Full Name
    POU class 2 homeobox 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-185
    See related
    AllianceGenome:ZFIN:ZDB-GENE-990415-185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    oct1; Oct-1; pouII1; zgc:109809
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See pou2f1a in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_018394426.1 (10585..23755)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (49205..61490, complement)

    NW_018394426.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 27 Neighboring gene wu:fj30f06 Neighboring gene CD247 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effect-directed analysis reveals inhibition of zebrafish uptake transporter Oatp1d1 by caulerpenyne, a major secondary metabolite from the invasive marine alga Caulerpa taxifolia. Marić P, et al. Chemosphere, 2017 May. PMID 28199941
    2. Organic cation transporters are determinants of oxaliplatin cytotoxicity. Zhang S, et al. Cancer Res, 2006 Sep 1. PMID 16951202, Free PMC Article
    3. Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure. Fero K, et al. Dis Model Mech, 2014 Feb. PMID 24203884, Free PMC Article
    4. Ecotoxicological profiling of selected cyanobacterial strains using multi-endpoint effect-directed analysis. Marić P, et al. Ecotoxicology, 2020 Jul. PMID 32297059
    5. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Tzvetkov MV, et al. Clin Pharmacol Ther, 2009 Sep. PMID 19536068

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal OCT1 expression may be important not only in relation to metformin but with respect to other drugs as well
      Title: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
    2. OCT1 and OCT2 are major determinants of the anticancer activity of oxaliplatin and may contribute to its antitumor specificity.
      Title: Organic cation transporters are determinants of oxaliplatin cytotoxicity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109809

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 2, transcription factor 1a
    Names
    octamer-binding transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039974.1 → NP_001035063.1  POU domain, class 2, transcription factor 1a isoform 2

      See identical proteins and their annotated locations for NP_001035063.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098520
      UniProtKB/TrEMBL
      Q4KMK8
      Conserved Domains (2) summary
      smart00352
      Location:151 → 225
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:253 → 307
      Homeobox; Homeobox domain

    2. NM_131438.1 → NP_571513.1  POU domain, class 2, transcription factor 1a isoform 1

      See identical proteins and their annotated locations for NP_571513.1

      Status: PROVISIONAL

      Source sequence(s)
      AF030519
      UniProtKB/TrEMBL
      O42276
      Conserved Domains (2) summary
      smart00352
      Location:176 → 250
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:278 → 332
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NW_018394426.1 Reference GRCz11 Primary Assembly

      Range
      10585..23755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials