cbsb cystathionine beta-synthase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cbsbprovided by ZNC
Official Full Name: cystathionine beta-synthase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021030-3
See related: Ensembl:ENSDARG00000010946 AllianceGenome:ZFIN:ZDB-GENE-021030-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cbs; cb442; wu:fb37g05; wu:fm61c07; wu:fq06c06; zgc:113704
Summary: Predicted to enable cystathionine beta-synthase activity. Acts upstream of or within axis elongation and regulation of homocysteine metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including digestive system; germ ring; immature eye; musculature system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (9183559..9228959, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (9205232..9250904, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cystathione beta-synthase regulates HIF-1alpha stability through persulfidation of PHD2.
Title: Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2.

Submit: New GeneRIF Correction

General gene information

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Markers

fb37g05.x1 (e-PCR)
- UniSTS:187139

AI416342 (e-PCR)
- UniSTS:206622

fb37g05.x1 (e-PCR)
- UniSTS:190536

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cystathionine beta-synthase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cysteine biosynthetic process via cystathionine	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process via cystathionine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of homocysteine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cystathionine beta-synthase b

NP_001014367.3

EC 4.2.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.