nsun2 NOP2/Sun RNA methyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nsun2provided by ZNC
Official Full Name: NOP2/Sun RNA methyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4017
See related: Ensembl:ENSDARG00000056665 AllianceGenome:ZFIN:ZDB-GENE-030131-4017
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55517; wu:fc65a08
Summary: Predicted to enable tRNA (cytidine-5-)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within RNA methylation and tRNA processing. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (27858866..27902509)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (28274592..28318286)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi59a06.y1 (e-PCR)
- UniSTS:197749

fc65a08.x1 (e-PCR)
- UniSTS:203976

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine-5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-5-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA cytosine C(5)-methyltransferase NSUN2

Names: NOL1/NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family, member 2

NP_956005.1

EC 2.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199711.1 → NP_956005.1 RNA cytosine C(5)-methyltransferase NSUN2

See identical proteins and their annotated locations for NP_956005.1

Status: PROVISIONAL

Source sequence(s)

BC045365

UniProtKB/TrEMBL

A0A0R4IU00, A0A8M2BH99, A0A8N7XJF7, A5PMI3, B2GQ21, Q7ZTI1

Related

ENSDARP00000138423.2, ENSDART00000161908.2

Conserved Domains (2) summary

TIGR00446
Location:12 → 363

nop2p; NOL1/NOP2/sun family putative RNA methylase

cl17173
Location:103 → 361

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...