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    stag2b STAG2 cohesin complex component b [ Danio rerio (zebrafish) ]

    Gene ID: 560751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stag2bprovided by ZNC
    Official Full Name
    STAG2 cohesin complex component bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2785
    See related
    Ensembl:ENSDARG00000053668 AllianceGenome:ZFIN:ZDB-GENE-030131-2785
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc17g12; wu:fc17g12
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within regulation of hematopoietic progenitor cell differentiation and regulation of vasculogenesis. Predicted to be located in chromatin. Predicted to be part of cohesin complex. Predicted to be active in nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See stag2b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (28486246..28527420)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (28180239..28221455)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2-like export factor 2 Neighboring gene proteasome 26S subunit, non-ATPase 10 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene zgc:113364 Neighboring gene hyaluronan-mediated motility receptor (RHAMM)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cohesin mutations are synthetic lethal with stimulation of WNT signaling. Chin CV, et al. Elife, 2020 Dec 7. PMID 33284104, Free PMC Article
    2. Cohesin composition and dosage independently affect early development in zebrafish. Labudina AA, et al. Development, 2024 Aug 1. PMID 38975838, Free PMC Article
    3. Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Ketharnathan S, et al. Front Cell Dev Biol, 2020. PMID 33365313, Free PMC Article
    4. Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Avagyan S, et al. Science, 2021 Nov 5. PMID 34735227
    5. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cohesin subunit SA-2
    Names
    stromal antigen 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      28486246..28527420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_681720.10 → XP_686812.5  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1F5, E7FE97
      Related
      ENSDARP00000082527.4, ENSDART00000088094.6
      Conserved Domains (1) summary
      pfam08514
      Location:150 → 258
      STAG; STAG domain

    2. XM_005173193.5 → XP_005173250.1  cohesin subunit SA-2 isoform X1

      See identical proteins and their annotated locations for XP_005173250.1

      UniProtKB/TrEMBL
      A0A0R4IZR5, A0A8M9Q574
      Related
      ENSDARP00000141467.1, ENSDART00000161852.2
      Conserved Domains (1) summary
      pfam08514
      Location:150 → 258
      STAG; STAG domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394911.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      32436..72572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472791.2 → XP_021328466.1  cohesin subunit SA-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q1F5, E7FE97
      Conserved Domains (1) summary
      pfam08514
      Location:150 → 258
      STAG; STAG domain

    2. XM_021472790.2 → XP_021328465.1  cohesin subunit SA-2 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IZR5, A0A8M9Q574
      Conserved Domains (1) summary
      pfam08514
      Location:150 → 258
      STAG; STAG domain
    Nucleotide Protein Strain
    Heading Accession and Version

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