hccsb holocytochrome c synthase b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hccsbprovided by ZNC
Official Full Name: holocytochrome c synthase bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000607-78
See related: Ensembl:ENSDARG00000099358 AllianceGenome:ZFIN:ZDB-GENE-000607-78
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hccs; id:ibd1278; wu:fb18h01; wu:fc64e12; wu:fi43e01
Summary: Predicted to enable holocytochrome-c synthase activity. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; musculature system; and retina. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (31081899..31092576, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (31144688..31155365, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb18h01.x1 (e-PCR)
- UniSTS:203026

fc64e12.x1 (e-PCR)
- UniSTS:203969

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables holocytochrome-c synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables holocytochrome-c synthase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: holocytochrome c-type synthase

Names: holocytochrome c synthetase b

NP_958859.1

EC 4.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.