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    ankhb ANKH inorganic pyrophosphate transport regulator b [ Danio rerio (zebrafish) ]

    Gene ID: 323738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ankhbprovided by ZNC
    Official Full Name
    ANKH inorganic pyrophosphate transport regulator bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2458
    See related
    Ensembl:ENSDARG00000014969 AllianceGenome:ZFIN:ZDB-GENE-030131-2458
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ankh; wu:fc08d03
    Summary
    Predicted to enable inorganic diphosphate transmembrane transporter activity and phosphate transmembrane transporter activity. Predicted to be involved in regulation of bone mineralization. Predicted to act upstream of or within phosphate ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ankhb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31957615..32006312)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31974397..32023094)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene amphiphysin Neighboring gene OTU deubiquitinase with linear linkage specificity b Neighboring gene si:ch211-139k8.2 Neighboring gene MYC proto-oncogene, bHLH transcription factor b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Marandel L, et al. Mol Reprod Dev, 2012 Feb. PMID 22213278
    2. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nürnberg P, et al. Nat Genet, 2001 May. PMID 11326272
    3. Generation and Validation of a Complete Knockout Model of abcc6a in Zebrafish. Van Gils M, et al. J Invest Dermatol, 2018 Nov. PMID 30030150
    4. Role of the mouse ank gene in control of tissue calcification and arthritis. Ho AM, et al. Science, 2000 Jul 14. PMID 10894769
    5. Macrophage-stimulating protein and calcium homeostasis in zebrafish. Huitema LF, et al. FASEB J, 2012 Oct. PMID 22787265, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91789

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables inorganic diphosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphate ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    progressive ankylosis protein homolog B
    Names
    ANK-B
    ankylosis, progressive homolog b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194370.1 → NP_919351.1  progressive ankylosis protein homolog B

      See identical proteins and their annotated locations for NP_919351.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ302035
      UniProtKB/Swiss-Prot
      B0UY66, P58368, Q66I27
      Related
      ENSDARP00000002526.7, ENSDART00000012413.8
      Conserved Domains (2) summary
      pfam07260
      Location:1 → 345
      ANKH; Progressive ankylosis protein (ANKH)
      cl09326
      Location:327 → 438
      MATE_like; Multidrug and toxic compound extrusion family and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31957615..32006312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58368.2 GenPept UniProtKB/Swiss-Prot:P58368

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