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    sgsm3 small G protein signaling modulator 3 [ Danio rerio (zebrafish) ]

    Gene ID: 406635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sgsm3provided by ZNC
    Official Full Name
    small G protein signaling modulator 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2635
    See related
    Ensembl:ENSDARG00000019038 AllianceGenome:ZFIN:ZDB-GENE-040426-2635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rutbc3; zgc:64026; wu:fa11c02
    Summary
    Predicted to enable GTPase activator activity. Is expressed in several structures, including chordo neural hinge; hatching gland; notochord; polster; and sensory system. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sgsm3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (33461075..33494166, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (33329361..33362477, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:dkey-283b1.7 Neighboring gene GTP binding protein 1 Neighboring gene protein phosphatase 1 regulatory subunit 29 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small G protein signaling modulator 3
    Names
    RUN and TBC1 domain containing 3
    RUN and TBC1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213330.1 → NP_998495.1  small G protein signaling modulator 3

      See identical proteins and their annotated locations for NP_998495.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054597
      UniProtKB/Swiss-Prot
      Q7T2D0
      UniProtKB/TrEMBL
      B2GRW4
      Related
      ENSDARP00000017428.8, ENSDART00000020342.10
      Conserved Domains (3) summary
      cd11813
      Location:488 → 540
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:112 → 326
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:567 → 720
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      33461075..33494166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164010.5 → XP_005164067.1  small G protein signaling modulator 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBH5
      Conserved Domains (3) summary
      cd11813
      Location:488 → 540
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:112 → 326
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:567 → 720
      RUN; RUN domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T2D0.1 GenPept UniProtKB/Swiss-Prot:Q7T2D0

    Gene LinkOut

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