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    arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b [ Danio rerio (zebrafish) ]

    Gene ID: 494081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgef7bprovided by ZNC
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 7bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-49
    See related
    Ensembl:ENSDARG00000073848 AllianceGenome:ZFIN:ZDB-GENE-041212-49
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bbh; bpix; arhgef7; im:7142367; wu:fc35h08; zgc:101775
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including endothelial cell proliferation; epiboly involved in gastrulation with mouth forming second; and protein localization to adherens junction. Predicted to be active in cytoplasm and lamellipodium. Is expressed in several structures, including EVL; axial vasculature; hatching gland; nervous system; and periderm. Used to study cerebrovascular disease. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgef7b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (45958906..46020725)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (45266965..45329148)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene lipoyltransferase 1 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene uncharacterized LOC103909161 Neighboring gene E3 ubiquitin-protein ligase RNF12-B-like Neighboring gene uncharacterized LOC137495286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA-Seq Dataset From Isolated Leukocytes Following Spontaneous Intracerebral Hemorrhage in Zebrafish Larvae. Crilly S, et al. Front Cell Neurosci, 2021. PMID 33935655, Free PMC Article
    2. Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage. Crilly S, et al. Dis Model Mech, 2022 Mar 1. PMID 35098999, Free PMC Article
    3. Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke. Crilly S, et al. J Vis Exp, 2019 Jun 5. PMID 31233021
    4. βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8. Liu J, et al. Dev Biol, 2012 Mar 1. PMID 22206757
    5. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Liu J, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17573532, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to adherens junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 7b
    Names
    Rho guanine exchange factor betaPix

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008624.1 → NP_001008624.1  rho guanine nucleotide exchange factor 7b

      See identical proteins and their annotated locations for NP_001008624.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086736
      UniProtKB/TrEMBL
      Q5PRA8
      Related
      ENSDARP00000100870.2, ENSDART00000108528.4
      Conserved Domains (9) summary
      cd11877
      Location:166 → 218
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      COG5199
      Location:1 → 170
      SCP1; Calponin [Cytoskeleton]
      cd01225
      Location:458 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:476 → 556
      PH; PH domain
      pfam00307
      Location:31 → 105
      CH; Calponin homology (CH) domain
      pfam00621
      Location:253 → 428
      RhoGEF; RhoGEF domain
      pfam16523
      Location:710 → 796
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:609 → 707
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:115 → 162
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      45958906..46020725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017354714.3 → XP_017210203.1  rho guanine nucleotide exchange factor 7b isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z5N5

    2. XM_021474150.2 → XP_021329825.1  rho guanine nucleotide exchange factor 7b isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q952
      Conserved Domains (7) summary
      cd11877
      Location:166 → 218
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:250 → 427
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:458 → 557
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00307
      Location:2 → 105
      CH; Calponin homology (CH) domain
      pfam16523
      Location:753 → 839
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:609 → 707
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:115 → 162
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

    3. XM_017354716.3 → XP_017210205.1  rho guanine nucleotide exchange factor 7b isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z512

    4. XM_017354718.3 → XP_017210207.1  rho guanine nucleotide exchange factor 7b isoform X4

      UniProtKB/TrEMBL
      A0A8M6YXL6, F1QA07
      Related
      ENSDARP00000042085.5, ENSDART00000042086.6
    Nucleotide Protein Strain
    Heading Accession and Version

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