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    si:ch211-214b16.3 si:ch211-214b16.3 [ Danio rerio (zebrafish) ]

    Gene ID: 564346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    si:ch211-214b16.3provided by ZNC
    Official Full Name
    si:ch211-214b16.3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081105-50
    See related
    Ensembl:ENSDARG00000074345 AllianceGenome:ZFIN:ZDB-GENE-081105-50
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-214b16.4
    Summary
    Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome (multiple); and urticaria. Orthologous to several human genes including NLRP12 (NLR family pyrin domain containing 12); NLRP13 (NLR family pyrin domain containing 13); and NLRP14 (NLR family pyrin domain containing 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See si:ch211-214b16.3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (60337975..60406192, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (60076983..60167521, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene zgc:112183 Neighboring gene NACHT, LRR and PYD domains-containing protein 3-like Neighboring gene si:ch211-214b16.2 Neighboring gene uncharacterized LOC103910353 Neighboring gene si:ch73-366l1.5 Neighboring gene methyltransferase 23, arginine Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Wu XM, et al. Front Immunol, 2018. PMID 29692779, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      60337975..60406192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219452.1 → XP_068075553.1  NACHT, LRR and PYD domains-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PZS7

    2. XM_068219453.1 → XP_068075554.1  NACHT, LRR and PYD domains-containing protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QAM3

    3. XM_068219451.1 → XP_068075552.1  NACHT, LRR and PYD domains-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PTT2
      Related
      ENSDARP00000136754.2, ENSDART00000160821.2

    4. XM_068219450.1 → XP_068075551.1  NACHT, LRR and PYD domains-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PTT2

    5. XM_068219449.1 → XP_068075550.1  NACHT, LRR and PYD domains-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PGP7

    6. XM_021474776.2 → XP_021330451.1  NACHT, LRR and PYD domains-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5L3, A0A8M9Q5L6, F1Q5P9
      Related
      ENSDARP00000113322.2, ENSDART00000144030.3
      Conserved Domains (6) summary
      cd00116
      Location:983 → 1292
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:1037 → 1065
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:1240 → 1268
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd16040
      Location:1309 → 1487
      SPRY_PRY_SNTX; Stonustoxin subunit alpha or SNTX subunit alpha
      pfam05729
      Location:507 → 674
      NACHT; NACHT domain
      pfam14484
      Location:418 → 486
      FISNA; Fish-specific NACHT associated domain
    Nucleotide Protein
    Heading Accession and Version

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