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    tubgcp2 tubulin gamma complex component 2 [ Danio rerio (zebrafish) ]

    Gene ID: 386975, updated on 4-Jan-2025

    Summary

    Official Symbol
    tubgcp2provided by ZNC
    Official Full Name
    tubulin gamma complex component 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-150
    See related
    Ensembl:ENSDARG00000013079 AllianceGenome:ZFIN:ZDB-GENE-031118-150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb81g10; zgc:63543; wu:fb81g10
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Acts upstream of or within brain development and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be part of gamma-tubulin complex. Human ortholog(s) of this gene implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. Orthologous to human TUBGCP2 (tubulin gamma complex component 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See tubgcp2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (9183626..9218255)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (9145783..9180412)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 8b Neighboring gene galanin receptor 2a-like Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 46 Neighboring gene parathyroid hormone 3 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gamma-tubulin complex component 2
    Names
    tubulin, gamma complex associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200122.1NP_956416.1  gamma-tubulin complex component 2

      See identical proteins and their annotated locations for NP_956416.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054908
      UniProtKB/TrEMBL
      Q7SYD6
      Related
      ENSDARP00000014990.7, ENSDART00000020192.9
      Conserved Domains (1) summary
      pfam04130
      Location:220738
      Spc97_Spc98; Spc97 / Spc98 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      9183626..9218255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)