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    capgb capping protein (actin filament), gelsolin-like b [ Danio rerio (zebrafish) ]

    Gene ID: 336597, updated on 4-Jan-2025

    Summary

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    Official Symbol
    capgbprovided by ZNC
    Official Full Name
    capping protein (actin filament), gelsolin-like bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8541
    See related
    Ensembl:ENSDARG00000099672 AllianceGenome:ZFIN:ZDB-GENE-030131-8541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    capg; fb14e07; zgc:86681; wu:fb14e07
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Orthologous to human CAPG (capping actin protein, gelsolin like). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See capgb in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (22576591..22604311)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (22455372..22483092)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene RNA polymerase II subunit A Neighboring gene si:dkey-219e21.2 Neighboring gene major facilitator superfamily domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Brain Regeneration Resembles Brain Cancer at Its Early Wound Healing Stage and Diverges From Cancer Later at Its Proliferation and Differentiation Stages. Demirci Y, et al. Front Cell Dev Biol, 2022. PMID 35223842, Free PMC Article
    2. Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo. Jerison ER, et al. Elife, 2020 May 19. PMID 32427565, Free PMC Article
    3. Analysis and functional evaluation of the hair-cell transcriptome. McDermott BM Jr, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606911, Free PMC Article
    4. Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Demirci Y, et al. Front Cell Dev Biol, 2020. PMID 33163496, Free PMC Article
    5. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Xue Y, et al. Dev Biol, 2015 Jul 15. PMID 26015096

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    capping protein (actin filament), gelsolin-like b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001594.2 → NP_001001594.2  capping protein (actin filament), gelsolin-like b

      Status: VALIDATED

      Source sequence(s)
      AW232766, EH443156, EH453176, EH469041
      UniProtKB/TrEMBL
      A0A0R4IML0, A0A8M1MZM8
      Related
      ENSDARP00000136284.1, ENSDART00000172053.2
      Conserved Domains (3) summary
      cd11289
      Location:134 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:11 → 119
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:245 → 343
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      22576591..22604311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480032.2 → XP_021335707.2  capping protein (actin filament), gelsolin-like b isoform X1

      Related
      ENSDARP00000149411.1, ENSDART00000192290.1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394840.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      3561..9968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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