tp53bp2a tumor protein p53 binding protein, 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tp53bp2aprovided by ZNC
Official Full Name: tumor protein p53 binding protein, 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040516-8
See related: Ensembl:ENSDARG00000009136 AllianceGenome:ZFIN:ZDB-GENE-040516-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tp53bp2; zgc:85720; wu:fa09h08; wu:fb04e08
Summary: Predicted to enable p53 binding activity. Acts upstream of or within chordate embryonic development and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in nucleus. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (646629..664473)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (516308..534205)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings uncover a novel role of Aspp2 in regulating vertebrate embryonic growth.
Title: Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

fa09h08.s1 (e-PCR)
- UniSTS:202271

AA495480 (e-PCR)
- UniSTS:206943

fb04e08.y1 (e-PCR)
- UniSTS:189861

aa495481 (e-PCR)
- UniSTS:186860

fc06e05.y1 (e-PCR)
- UniSTS:192255

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables p53 binding	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: apoptosis-stimulating of p53 protein 2a

Names: aspp2a; tumor protein p53 binding protein, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214814.1 → NP_999979.1 apoptosis-stimulating of p53 protein 2a

See identical proteins and their annotated locations for NP_999979.1

Status: PROVISIONAL

Source sequence(s)

BC070005

UniProtKB/TrEMBL

Q6NSN9

Related

ENSDARP00000010764.9, ENSDART00000006892.11

Conserved Domains (6) summary

cd00204
Location:868 → 979

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:862 → 948

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:862 → 888

ANK; ANK repeat [structural motif]

cl00155
Location:22 → 83

UBQ; Ubiquitin-like proteins

cl17036
Location:992 → 1048

SH3; Src Homology 3 domain superfamily

cl23720
Location:170 → 301

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

646629..664473

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068212831.1 → XP_068068932.1 apoptosis-stimulating of p53 protein 2a isoform X1

UniProtKB/TrEMBL

A0A8M2B382, F1R419
XM_068212832.1 → XP_068068933.1 apoptosis-stimulating of p53 protein 2a isoform X1

UniProtKB/TrEMBL

A0A8M2B382, F1R419
XM_068212833.1 → XP_068068934.1 apoptosis-stimulating of p53 protein 2a isoform X2

UniProtKB/TrEMBL

A0A8M2B2J1